G
Gen Sobue
Researcher at Nagoya University
Publications - 978
Citations - 41534
Gen Sobue is an academic researcher from Nagoya University. The author has contributed to research in topics: Spinal and bulbar muscular atrophy & Amyotrophic lateral sclerosis. The author has an hindex of 91, co-authored 947 publications receiving 36378 citations. Previous affiliations of Gen Sobue include Yokohama City University & Children's Hospital of Philadelphia.
Papers
More filters
Journal ArticleDOI
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
Hiroshi Inoue,Yukio Tanizawa,Jon Wasson,Philip Behn,Kamini Kalidas,Ernesto Bernal-Mizrachi,Mike Mueckler,Helen Marshall,Helen Donis-Keller,Patricia Crock,Douglas Rogers,Masahiko Mikuni,Hisashi Kumashiro,Koichiro Higashi,Gen Sobue,Yoshitomo Oka,M. Alan Permutt +16 more
TL;DR: In this paper, the authors localized the Wolfram syndrome (WFS) gene to a BAC/P1 contig of less than 250 kb and found that mutations in a novel gene encoding a putative transmembrane protein were associated with the disease phenotype.
Journal ArticleDOI
Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
Koji Abe,Masashi Aoki,Shoji Tsuji,Yasuto Itoyama,Gen Sobue,Masanori Togo,Chikuma Hamada,Masahiko Tanaka,Makoto Akimoto,Kazue Nakamura,Fumihiro Takahashi,Kazuoki Kondo,Hiide Yoshino,Hidenao Sasaki,Ichiro Yabe,Shizuki Doi,Hitoshi Warita,Takashi Imai,Hiroaki Ito,Mitsumasa Fukuchi,Etsuko Osumi,Manabu Wada,Imaharu Nakano,Mitsuya Morita,Katsuhisa Ogata,Yuichi Maruki,Kimiko Ito,Osamu Kano,Mineo Yamazaki,Yuji Takahashi,Hiroyuki Ishiura,Mieko Ogino,Ryoko Koike,Chiho Ishida,Tsuyoshi Uchiyama,Kouichi Mizoguchi,Tomokazu Obi,Hirohisa Watanabe,Naoki Atsuta,Ikuko Aiba,Akira Taniguchi,Hideyuki Sawada,Takanori Hazama,Harutoshi Fujimura,Hirofumi Kusaka,Takenobu Kunieda,Hitoshi Kikuchi,Hidenori Matsuo,Hidetsugu Ueyama,Kazutoshi Uekawa,Masaki Ueda,Aiko Murakami,Rie Sumii,Takuya Kudou,Kazunori Morimoto,Takatomo Yoneoka,Manabu Hirai,Kouichi Sasaki,Hidetomo Terai,Tomoko Natori,Hiroshi Matsui,Kuniko Kotani,Kaori Yoshida,Tomohisa Iwasaki +63 more
TL;DR: The primary efficacy outcome was the change in ALSFRS-R score from the baseline to 24 weeks (or at discontinuation if this was after the third cycle) after randomisation and the least-squares mean difference between groups was 2·49 (SE 0·76, 95% CI 0·99-3·98) in favour of edaravone.
Journal ArticleDOI
CREB-binding protein sequestration by expanded polyglutamine
Alexander McCampbell,J. Paul Taylor,Addis A. Taye,Jon Robitschek,Mei Li,Jessica L. Walcott,Diane E. Merry,Yaohui Chai,Henry L. Paulson,Gen Sobue,Kenneth H. Fischbeck +10 more
TL;DR: Evidence is presented that CREB-binding protein (CBP), a transcriptional co-activator that orchestrates nuclear response to a variety of cell signaling cascades, is incorporated into nuclear inclusions formed by polyglutamine-containing proteins in cultured cells, transgenic mice and tissue from patients with SBMA.
Journal ArticleDOI
Amyotrophic lateral sclerosis
Eva L. Feldman,Stephen A. Goutman,Susanne Petri,Letizia Mazzini,Masha G. Savelieff,Pamela J. Shaw,Gen Sobue +6 more
TL;DR: Two possible disease-modifying therapies that can slow disease progression are available for ALS, but patient management is largely mediated by symptomatic therapies, such as the use of muscle relaxants for spasticity and speech therapy for dysarthria.
Journal ArticleDOI
Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients.
Hirohisa Watanabe,Yufuko Saito,Shin-ichi Terao,Tetsuo Ando,Teruhiko Kachi,Eiichiro Mukai,Ikuko Aiba,Yuji Abe,Akiko Tamakoshi,Manabu Doyu,Masaaki Hirayama,Gen Sobue +11 more
TL;DR: The interval from initial symptom to combined motor and autonomic dysfunction can predict functional deterioration and survival in MSA, and the relationship between atrophy and functional status was highly variable among the individuals, suggesting that other factors influenced the functional deterioration.