M
Masahiro Nagasawa
Researcher at Gunma University
Publications - 34
Citations - 1354
Masahiro Nagasawa is an academic researcher from Gunma University. The author has contributed to research in topics: Insulin receptor & Receptor. The author has an hindex of 17, co-authored 34 publications receiving 1208 citations.
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Journal ArticleDOI
Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion
Yuko Nakagawa,Masahiro Nagasawa,Satoko Yamada,Akemi Hara,Hideo Mogami,Viacheslav O. Nikolaev,Martin J. Lohse,Noriatsu Shigemura,Yuzo Ninomiya,Itaru Kojima +9 more
TL;DR: Sweet taste receptor is expressed in β-cells, and activation of this receptor induces insulin secretion by Ca2+ and cAMP-dependent mechanisms.
Journal ArticleDOI
Molecular identification of a eukaryotic, stretch-activated nonselective cation channel.
Makoto Kanzaki,Masahiro Nagasawa,Itaru Kojima,Chikara Sato,Keiji Naruse,Masahiro Sokabe,Hidetoshi Iida +6 more
TL;DR: Functional expression of Mid1 in Chinese hamster ovary cells conferred sensitivity to mechanical stress that resulted in increases in both calcium conductance and the concentration of cytosolic free calcium, and Mid1 appears to be a eukaryotic, SA Cat channel.
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Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells
TL;DR: TRPV2 is regulated by insulin and is involved in the autocrine action of this hormone on β-cells, and knockdown of TRPV 2 reduced insulin secretion induced by glucose.
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Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages
TL;DR: FMLP induces translocation of TRPV2 from intracellular compartment to the plasma membrane, and this translocation is critical for fMLP‐induced calcium entry.
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Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists.
TL;DR: Monitoring changes in cytoplasmic Ca2+ and cAMP induced by four sweet taste receptor agonists indicates that four types of sweeteners activate thesweet taste receptor differently and generate distinct patterns of intracellular signals.