K
Kohjiro Ueki
Researcher at University of Tokyo
Publications - 213
Citations - 27673
Kohjiro Ueki is an academic researcher from University of Tokyo. The author has contributed to research in topics: Diabetes mellitus & Insulin resistance. The author has an hindex of 60, co-authored 188 publications receiving 25194 citations. Previous affiliations of Kohjiro Ueki include Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
Journal ArticleDOI
CD8 + effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Satoshi Nishimura,Ichiro Manabe,Mika Nagasaki,Koji Eto,Hiroshi Yamashita,Mitsuru Ohsugi,Makoto Otsu,Hara Kazuo,Kohjiro Ueki,Seiryo Sugiura,Kotaro Yoshimura,Takashi Kadowaki,Ryozo Nagai +12 more
TL;DR: The findings suggest that obese adipose tissue activates CD8+ T cells, which, in turn, promote the recruitment and activation of macrophages in this tissue, which supports the notion that CD8- T cells have an essential role in the initiation and propagation of adipose inflammation.
Journal Article
Report of the committee on the classification and diagnostic criteria of diabetes mellitus (revision for international harmonization of HbAle in Japan)
Yoshiki Seino,Kishio Nanjo,Naoko Tajima,Takashi Kadowaki,Atsunori Kashiwagi,Eiichi Araki,Chikako Ito,Nobuya Inagaki,Yasuhiko Iwamoto,Masato Kasuga,Toshiaki Hanafusa,Masakazu Haneda,Kohjiro Ueki +12 more
TL;DR: Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action, which can cause susceptibility to specific complications and also foster arteriosclerosis.
Journal ArticleDOI
Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus
Yutaka Seino,Kishio Nanjo,Naoko Tajima,Takashi Kadowaki,Atsunori Kashiwagi,Eiichi Araki,Chikako Ito,Nobuya Inagaki,Yasuhiko Iwamoto,Masato Kasuga,Toshiaki Hanafusa,Masakazu Haneda,Kohjiro Ueki +12 more
TL;DR: The concept of diabetes mellitus as mentioned in this paper is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action.
Journal ArticleDOI
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Toshimasa Yamauchi,Yasunori Nio,Toshiyuki Maki,Masaki Kobayashi,Takeshi Takazawa,Masato Iwabu,Miki Okada-Iwabu,Sachiko Kawamoto,Naoto Kubota,Tetsuya Kubota,Yusuke Ito,Junji Kamon,Atsushi Tsuchida,Katsuyoshi Kumagai,Hideki Kozono,Yusuke Hada,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Kouji Murakami,Motoharu Awazawa,Iseki Takamoto,Philippe Froguel,Kazuo Hara,Kazuyuki Tobe,Ryozo Nagai,Kohjiro Ueki,Takashi Kadowaki +28 more
TL;DR: Adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr−/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively, and abolished adiponectin binding and actions, leading to insulin resistance and marked glucose intolerance in vivo.