M
Masaki Kimura
Researcher at Keio University
Publications - 45
Citations - 816
Masaki Kimura is an academic researcher from Keio University. The author has contributed to research in topics: Stem cell & Organoid. The author has an hindex of 17, co-authored 45 publications receiving 708 citations. Previous affiliations of Masaki Kimura include University of Queensland.
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Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis.
Yoko Takaki,Yoshimasa Saito,Azusa Takasugi,Kohta Toshimitsu,Shoji Yamada,Toshihide Muramatsu,Masaki Kimura,Kazuo Sugiyama,Hiromu Suzuki,Eri Arai,Hidenori Ojima,Yae Kanai,Hidetsugu Saito +12 more
TL;DR: Results suggest that silencing of miR‐122 is an early event during hepatocarcinogenesis from NASH, and that miR-122 could be a novel molecular marker for evaluating the risk of HCC in patients with NASH.
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The Effect of Female Hormones Upon Urate Transport Systems in the Mouse Kidney
TL;DR: This study investigated the regulation of renal urate transporter expression by female hormones using ovariectomized mice with or without hormone replacement, and found neither estradiol nor progesterone influenced the respective levels of mRNA.
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Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells.
Sana Hibino,Yoshimasa Saito,Toshihide Muramatsu,A Otani,Yusuke Kasai,Masaki Kimura,Hidetsugu Saito +6 more
TL;DR: Findings suggest that EZH2 inhibitors such as SAHA and DZNep exert multiple anticancer effects through activation of tumor-suppressor miRNAs.
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Coffee extract inhibits adipogenesis in 3T3-L1 preadipocyes by interrupting insulin signaling through the downregulation of IRS1
Chihiro Maki,Megumi Funakoshi-Tago,Ryohei Aoyagi,Fumihito Ueda,Masaki Kimura,Kenji Kobata,Kenji Tago,Hiroomi Tamura +7 more
TL;DR: Coffee intake significantly suppressed high-fat diet (HFD)-induced metabolic alternations such as increases in body weight and the accumulation of adipose tissue, and up-regulation of glucose, free fatty acid, total cholesterol and insulin levels in the blood.
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Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.
Shoji Yamada,Nobuhiko Kamada,Takeru Amiya,Nobuhiro Nakamoto,Toshiaki Nakaoka,Masaki Kimura,Yoshimasa Saito,Chieko Ejima,Takanori Kanai,Hidetsugu Saito +9 more
TL;DR: Lipid metabolism by the gut microbiota, particularly the saturation of fatty acids, affects fat accumulation in the liver and subsequent liver inflammation in NASH.