T
Takeru Amiya
Researcher at Keio University
Publications - 9
Citations - 227
Takeru Amiya is an academic researcher from Keio University. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 5, co-authored 7 publications receiving 149 citations. Previous affiliations of Takeru Amiya include Mitsubishi Tanabe Pharma & Mitsubishi Chemical Corporation.
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Journal ArticleDOI
Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice.
Nobuhiro Nakamoto,Takeru Amiya,Takeru Amiya,Ryo Aoki,Ryo Aoki,Nobuhito Taniki,Yuzo Koda,Yuzo Koda,Kentaro Miyamoto,Toshiaki Teratani,Takahiro Suzuki,Sayako Chiba,Po Sung Chu,Atsushi Hayashi,Akihiro Yamaguchi,Shunsuke Shiba,Rei Miyake,Tadashi Katayama,Wataru Suda,Wataru Suda,Yohei Mikami,Nobuhiko Kamada,Hirotoshi Ebinuma,Hidetsugu Saito,Masahira Hattori,Masahira Hattori,Takanori Kanai +26 more
TL;DR: It is found that recruitment of immune-regulatory classical dendritic cells (cDCs) is crucial for liver tolerance in concanavalin A-induced acute liver injury and that beneficial gut microbes influence tolerogenic immune responses in the liver.
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On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C
Po Sung Chu,Nobuhiro Nakamoto,Nobuhito Taniki,Keisuke Ojiro,Takeru Amiya,Yuko Makita,Yuko Makita,Hiroko Murata,Akihiro Yamaguchi,Shunsuke Shiba,Rei Miyake,Tadashi Katayama,Aya Ugamura,Akihiko Ikura,Karin Takeda,Hirotoshi Ebinuma,Hirotoshi Ebinuma,Hidetsugu Saito,Takanori Kanai +18 more
TL;DR: Higher pre-treatment NKG2D expression, higher FIB-4 score, previous HCC history and failure to achieve sustained viral response were significant factors correlating to early HCC emergence.
Journal ArticleDOI
Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis.
Shoji Yamada,Nobuhiko Kamada,Takeru Amiya,Nobuhiro Nakamoto,Toshiaki Nakaoka,Masaki Kimura,Yoshimasa Saito,Chieko Ejima,Takanori Kanai,Hidetsugu Saito +9 more
TL;DR: Lipid metabolism by the gut microbiota, particularly the saturation of fatty acids, affects fat accumulation in the liver and subsequent liver inflammation in NASH.
Journal ArticleDOI
Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis.
Takeru Amiya,Nobuhiro Nakamoto,Po Sung Chu,Toshiaki Teratani,Hideaki Nakajima,Yumi Fukuchi,Nobuhito Taniki,Akihiro Yamaguchi,Shunsuke Shiba,Rei Miyake,Tadashi Katayama,Hirotoshi Ebinuma,Takanori Kanai +12 more
TL;DR: This study demonstrates that inflammatory Mφs originate from BM and became locally differentiated and proliferated by interaction with HSCs via CCR9 axis during acute liver injury.
Journal ArticleDOI
Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
Rei Morikawa,Nobuhiro Nakamoto,Takeru Amiya,Takeru Amiya,Po Sung Chu,Yuzo Koda,Yuzo Koda,Toshiaki Teratani,Takahiro Suzuki,Yutaka Kurebayashi,Akihisa Ueno,Nobuhito Taniki,Kentaro Miyamoto,Akihiro Yamaguchi,Shunsuke Shiba,Tadashi Katayama,Kosuke Yoshida,Yoshiaki Takada,Rino Ishihara,Hirotoshi Ebinuma,Hirotoshi Ebinuma,Michiie Sakamoto,Takanori Kanai +22 more
TL;DR: It is shown that CCR9 blockade attenuated the development of NAFLD-related hepatocellular carcinoma in mice injected with diethylnitrosamine under HF diet, providing new insights into therapeutic strategies for NASH.