Takanori Kanai

TL;DR: The results suggest that 'driver' pathway mutations enable stem cell maintenance in the hostile tumor microenvironment, but that additional molecular lesions are required for invasive behavior.

TL;DR: A number of trials have shown that therapies correcting dysbiosis, including fecal microbiota transplantation and probiotics, are promising in IBD, and it has not yet been established how Dysbiosis contributes to intestinal inflammation.

TL;DR: It is found that niche-independent growth is predominantly associated with the adenoma-carcinoma transition reflecting accumulation of multiple mutations and underscores the importance of genotype-phenotype analyses at a single-patient level and the value of the resource to provide insights into colorectal tumorigenesis and patient-centered therapeutic development.

TL;DR: It is shown that human L GR5+ colorectal cancer cells serve as CSCs in growing cancer tissues and combined chemotherapy potentiates targeting of LGR5+ C SCs.

TL;DR: This English version was produced and edited based on the existing updated guidelines for ulcerative colitis and Crohn’s disease in Japanese, developed with the basic concept of the Grading of Recommendations Assessment, Development, and Evaluation system.