Showing papers by "Masamichi Takami published in 2020"
TL;DR: The findings indicated that mTOR signaling plays important roles in bone formation and neural networking during fracture healing, and the first to show the dynamics of myelinating cells in vivo.
11 citations
TL;DR: Important effects of lipid metabolism, especially via the LDL receptor, on tooth homeostasis maintenance are shown, and a different mechanism for WT and Ldlr −/− mice is suggested, though the LDL receptors may not be the only factor involved.
Abstract: Tooth formation can be affected by various factors, such as oral disease, drug administration, and systemic illness, as well as internal conditions including dentin formation. Dyslipidemia is an important lifestyle disease, though the relationship of aberrant lipid metabolism with tooth formation has not been clarified. This study was performed to examine the effects of dyslipidemia on tooth formation and tooth development. Dyslipidemia was induced in mice by giving a high-fat diet (HFD) for 12 weeks. Additionally, LDL receptor-deficient (Ldlr-/-) strain mice were used to analyze the effects of dyslipidemia and lipid metabolism in greater detail. In the HFD-fed mice, incisor elongation was decreased and pulp was significantly narrowed, while histological findings revealed disappearance of predentin. In Ldlr-/- mice fed regular chow, incisor elongation showed a decreasing trend and pulp a narrowing trend, while predentin changes were unclear. Serum lipid levels were increased in the HFD-fed wild-type (WT) mice, while Ldlr-/- mice given the HFD showed the greatest increase. These results show important effects of lipid metabolism, especially via the LDL receptor, on tooth homeostasis maintenance. In addition, they suggest a different mechanism for WT and Ldlr-/- mice, though the LDL receptor pathway may not be the only factor involved.
7 citations
TL;DR: Findings indicating that the newly characterized gene Merlot, which encodes a highly conserved yet uncharacterized protein in vertebrates, is an important regulator for termination of osteoclastogenesis via induction of apoptosis are presented.
6 citations
TL;DR: It is indicated that blockade of the NMDA receptor by MK-801 administration affects bone metabolism but not the healing process of artificial bone defects.
2 citations
TL;DR: LPS suppresses the ectopic bone formation induced by BMP-2 and TGF-β1 through IL-1β production and significantly increased the osteoblast number and osteoid volume, while the osteoclast number did not change.
2 citations