M
Masaru Yoshinaga
Researcher at Kumamoto University
Publications - 57
Citations - 1889
Masaru Yoshinaga is an academic researcher from Kumamoto University. The author has contributed to research in topics: Arthritis & Tumor necrosis factor alpha. The author has an hindex of 23, co-authored 57 publications receiving 1849 citations.
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Journal ArticleDOI
Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation.
Octavio Ramilo,Xavier Sáez-Llorens,Jussi Mertsola,Hamid Jafari,Kurt Olsen,Eric J. Hansen,Masaru Yoshinaga,Susumu Ohkawara,Hideo Nariuchi,George H. McCracken +9 more
TL;DR: In this paper, homologous cytokines were applied to the rabbit meningitis model, and the results provided evidence for a seminal role of TNF-alpha and IL-1 beta in the initial events of meningeal inflammation.
Journal Article
Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo.
Akihiro Matsukawa,T Yoshimura,Takako Maeda,Susumu Ohkawara,Katsumasa Takagi,Masaru Yoshinaga +5 more
TL;DR: Rabbit IL-8 proved to have a neutrophil-activating capability in vivo, with respect to release of neutrophIL elastase and induction of IL-1 beta andIL-1Ra, and the infiltrating neutrophils are the main producers of these cytokines and are responsible for the cartilage destruction.
Journal Article
Analysis of the cytokine network among tumor necrosis factor alpha, interleukin-1beta, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis.
Akihiro Matsukawa,Teizo Yoshimura,Takako Maeda,Toshihiro Takahashi,Susumu Ohkawara,Masaru Yoshinaga +5 more
TL;DR: The intravenous injection of colchicine inhibited neutrophil infiltration without affecting the production of TNFalpha or the first peak of IL-8, suggesting that col chicine inhibits MSU crystal-induced arthritis by directly inhibiting the migration of neutrophils.
Journal Article
Analysis of the inflammatory cytokine network among TNF alpha, IL-1 beta, IL-1 receptor antagonist, and IL-8 in LPS-induced rabbit arthritis.
TL;DR: New evidence is provided that IL-8 as well as TNF alpha are the most proximal cytokines and induce subsequent production of IL-1 beta and IL- 1Ra, and the possibility that factor(s) other thanIL-8 may be involved in the leukocyte influx in LPS-induced arthritis is raised.
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Production of IL-1 and IL-1 receptor antagonist and the pathological significance in lipopolysaccharide-induced arthritis in rabbits.
TL;DR: The results suggest that L PS‐initiated IL‐1 acts as a key mediator in LPS‐arthritis and that endogenous IL‐ 1 Ra may suppress a part of IL‐2 activity at the site, but its amount was too low for suppression of the produced IL‐3.