Masato Inazu

TL;DR: It is concluded that extracellular choline is mainly transported via a CTL1 that relies on a directed H(+) gradient as a driving force, and may be the major site for the control of choline oxidation in mitochondria and hence for the supply of endogenous betaine and S-adenosyl methionine.

TL;DR: Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives are disclosed in this article, where the compounds are represented by the formula (I), ##STR1

TL;DR: Investigation of the inhibitory effects of N(G)-nitro-L-arginine methyl ester (L-NAME), a non-selective NOS inhibitor, and S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBITU) on intraocular NO production in EIU rabbits suggests that activation of iNOS may play a key role in the development of EIU

TL;DR: It is suggested that sepsis induced by cecal ligation alters cerebral redox status and supports a proapoptotic phenotype, and the free radical scavenger edavarone reduces mortality of septic mice and protects against sepsi-induced neuronal cell death.

TL;DR: The functional expression and physiological role of carnitine transporters in central nervous system is further discussed and they may involve both the cholinergic neuronal transmission activity of acetyl-L-carnitine and its ability to enhance neuronal metabolism in mitochondria.