Masato Inazu

TL;DR: Results suggest that the uptake of extracellular choline in MIA PaCa-2 cells is mediated by CTL1, a target molecule for the treatment of pancreatic cancer, and its inhibitors Amb4269951 and Amb4269675 are novel lead compounds.

TL;DR: It is concluded that extracellular choline is mainly transported via a CTL1- and CTL2-mediated choline transport system, which is both Na+-independent and pH-dependent and provides a potential new target for esophageal cancer therapy.

TL;DR: Whether macrolides exhibit cytotoxic effect under an amino acid-starving condition in head and neck squamous cancer cell lines such as CAL 27 and Detroit 562 as models of solid tumors with an upregulated autophagy in the central region owing to hypovascularity is examined to suggest the possibility of using macrolide antibiotics for “tumor- starving therapy”.

TL;DR: The present results suggest that choline is mainly transported via a high-affinity choline transport system (CTL1) and a low-Affinity ch Caroline transport system(CTL2) in human trophoblastic JEG-3 cells, which play an important role in the growth of the fetus.

TL;DR: This work investigated whether simultaneous inhibition of protein degradation systems such as the ubiquitin-proteasome system by BZ and the autophagy-lysosomes system by a macrolide antibiotic enhances ER-stress-mediated apoptosis in MM cells.