M
Masato Inazu
Researcher at Tokyo Medical University
Publications - 70
Citations - 1843
Masato Inazu is an academic researcher from Tokyo Medical University. The author has contributed to research in topics: Choline & Choline transporter. The author has an hindex of 24, co-authored 66 publications receiving 1599 citations.
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Journal ArticleDOI
A Novel Plant-Derived Choline Transporter-like Protein 1 Inhibitor, Amb544925, Induces Apoptotic Cell Death via the Ceramide/Survivin Pathway in Tongue Squamous Cell Carcinoma
Kaoru Shibata,Nozomi Nishijima,Kaho Hirai,Saiichiro Watanabe,Tsuyoshi Yamanaka,Daichi Chikazu,Masato Inazu +6 more
TL;DR: The plant-derived CTL1 inhibitor Amb544925 is a lead compound of a new anticancer agent exhibiting antitumor effects and inhibition of cell migration through the ceramide/survivin pathway.
Journal ArticleDOI
Novel Diphenylalkyl Piperazine Derivatives with Dual Calcium Antagonistic and Antioxidative Activities.
Makoto Kimura,Tomoko Masuda,Koji Yamada,Nobuo Kubota,Nobuyuki Kawakatsu,Masaki Mitani,Kenichi Kishii,Masato Inazu,Takayuki Namiki +8 more
TL;DR: In this paper, two diphenylalkyl piperazine derivatives containing the thio or aminopropanol moiety substituted by phenyl or benzyl group were synthesized, and evaluated for their calcium antagonistic and antioxidative activities.
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Effects of LP-805, a new vasodilating agent, on cytosolic Ca2+ and contraction in vascular smooth muscle of rat aorta.
TL;DR: The results suggest that a vasodilatory effect of LP-805 might account for inhibiting the mobilization of external Ca2+ through receptor mediated passway and the Ca 2+ release from a ryanodine sensitive Ca2- store.
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Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells.
Takuya Ishikawa,Hirotsugu Suwanai,Junpei Shikuma,Ryo Suzuki,Tsuyoshi Yamanaka,Masato Odawara,Masato Inazu +6 more
TL;DR: The results of current study indicated that extracellular choline is primarily transported via CTL1, relying on a direct H+ gradient that functions as a driving force in Fa2N-4 cells, which provides further insights into the pathogenesis of liver disease involving choline metabolism.
Journal ArticleDOI
Functional Expression of Choline Transporters in Human Neural Stem Cells and Its Link to Cell Proliferation, Cell Viability, and Neurite Outgrowth.
TL;DR: In this article, the effect of extracellular choline uptake inhibition on the cellular activities in human neural stem cells (hNSCs) was investigated, and it was found that the mRNAs and proteins of choline transporter-like protein 1 (CTL1) and CTL2 were expressed at high levels.