M
Massimo Donadelli
Researcher at University of Verona
Publications - 96
Citations - 10208
Massimo Donadelli is an academic researcher from University of Verona. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 35, co-authored 89 publications receiving 8125 citations. Previous affiliations of Massimo Donadelli include Vision-Sciences, Inc. & Academy of Sciences of the Czech Republic.
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Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells.
Andrea Galbiati,Š. Bova,Raffaella Pacchiana,Chiara Borsari,Marco Persico,Aureliano Zana,Stefano Bruno,Massimo Donadelli,Caterina Fattorusso,Paola Conti +9 more
TL;DR: Among a series of 5-substituted 3-bromo-4,5-dihydroisoxazole (BDHI) derivatives, the spirocyclic compound 11, which is able to covalently inactivate recombinant human GAPDH with a faster reactivity than koningic acid, one of the most potent hGAPDH inhibitors known to date, was identified in this paper .