Massimo Donadelli

TL;DR: An extensive examination of the role of succinate in cancer development through the induction of epigenetic and metabolic alterations and the effects on epithelial to mesenchymal transition, cell migration and invasion, and angiogenesis is reported.

TL;DR: It is demonstrated for the first time that UCP2 plays a role in autophagy regulation bringing new insights into mitochondrial uncoupling protein field.

TL;DR: Investigation of changes in global gene expression observed after treatment of different pancreatic cancer cell lines with the methylase inhibitor 5-aza-2′-deoxycytidine found increased p21WAF1 and gadd45A expression to be associated with the efficacy of the treatment and induction of interferon-related genes may correlate with activation of the IFN signalling pathway.

TL;DR: It is demonstrated that TSA can effectively increase the drug sensitivity of all the cell lines studied and may represent an experimental basis for potential clinical application of HDAC inhibitors, in particular in association with drugs used in cancer clinical treatment, supporting the idea thatHDAC inhibitors could act as sensitizers for chemotherapy.

TL;DR: One prominent feature was the increased ratio between the levels of expression of pro-APoptotic and anti-apoptotic genes, which was confirmed in eight additional pancreatic cancer cell lines after treatment with TSA, suggesting that this event may be a strong determinant for the induction of apoptosis by TSA.