M
Massimo Pietropaolo
Researcher at University of Michigan
Publications - 92
Citations - 5669
Massimo Pietropaolo is an academic researcher from University of Michigan. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 35, co-authored 84 publications receiving 5321 citations. Previous affiliations of Massimo Pietropaolo include University of Pittsburgh & University of Colorado Hospital.
Papers
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Journal ArticleDOI
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
Alberto Pugliese,Markus Zeller,Alarico Fernandez,Laura J. Zalcberg,Richard J. Bartlett,Camillo Ricordi,Massimo Pietropaolo,George S. Eisenbarth,Simon T. Bennett,Dhavalkumar D. Patel +9 more
TL;DR: It is shown that during fetal development and childhood, mRNAs for insulin and other islet cell autoantigens are expressed at low levels in the human thymus, and this finding provides a plausible explanation for the dominant protective effect of class III VNTRs, and suggests that diabetes susceptibility and resistance associated with IDDM2 may derive from the VN TR influence on INS transcription in the thymos.
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Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies.
Charles F. Verge,Roberto Gianani,Eiji Kawasaki,Liping Yu,Massimo Pietropaolo,Richard A. Jackson,H. P. Chase,George S. Eisenbarth +7 more
TL;DR: It is concluded that the presence of two or more autoantibodies (out of IAAs, GAAs, and ICA512bdcAAs) is highly predictive of the development of type I diabetes among relatives.
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Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.
Massimo Pietropaolo,L Castaño,Sunanda R. Babu,R Buelow,Y L Kuo,S Martin,A Martin,Alvin C. Powers,M Prochazka,J Naggert +9 more
TL;DR: Large amounts of antigen are available for development of quantitative, convenient predictive assays for autoantibodies and analysis of the role of this molecule in diabetes autoimmunity, as well as its physiologic function.
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The emerging role of autophagy in the pathophysiology of diabetes mellitus
Claudio Gonzalez,Myung-Shik Lee,Piero Marchetti,Massimo Pietropaolo,Roberto Towns,Maria I. Vaccaro,Hirotaka Watada,John W. Wiley +7 more
TL;DR: The literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems is reviewed.
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Changing Prevalence of Overweight Children and Adolescents at Onset of Insulin-Treated Diabetes
TL;DR: At onset of the disease, the prevalence of being overweight has tripled from the 1980s to the 1990s, following the trend in the general population.