Massimo Venditti

TL;DR: The high ability of Muse cells to cope with genotoxic stress is related to their quick and efficient sensing of DNA damage and activation of DNA repair systems.

TL;DR: The results imply that Zn could prevent Cd‐induced testicular toxicity and sperm quality alteration in adult male rat after gestational and lactational exposure, probably via the restoration of the testicular DAAM1 expression inhibited by Cd.

TL;DR: In this article, the effects of melatonin co-treatment on male rat testis were investigated, and it was shown that its administration decreased the level of oxidative damage caused by Cd with reversal of all the observed changes.

TL;DR: The hypothesis of a role for DAAM1 in cytoskeletal organization during Mammalian testis morphogenesis and gamete progression is supported, for the first time, while also hinting at its possible investigation as a morphological marker of germ cell and sperm physiology.

TL;DR: It is revealed that ex vivo drug sensitivity testing in three-dimensional spheroidal culture can reproduce clinical response to chemotherapy and immunotherapy, with the potential to use those culture models to predict patients’ outcome from anticancer treatments and, therefore, the feasibility to select individualised therapy.