M
Matteo A. Molè
Researcher at University of Cambridge
Publications - 14
Citations - 524
Matteo A. Molè is an academic researcher from University of Cambridge. The author has contributed to research in topics: Neural tube & Neurulation. The author has an hindex of 8, co-authored 13 publications receiving 274 citations. Previous affiliations of Matteo A. Molè include University College London & UCL Institute of Child Health.
Papers
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Journal ArticleDOI
Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.
Gabriel L. Galea,Young-June Cho,Gauden Galea,Matteo A. Molè,Ana Rolo,Dawn Savery,Dale Moulding,Lucy H. Culshaw,Evanthia Nikolopoulou,Nicholas D. E. Greene,Andrew J. Copp +10 more
TL;DR: Biomechanical coupling of the entire region of active spinal neurulation in the mouse embryo is identified as a prerequisite for successful NT closure, using mouse embryos to investigate the biomechanics of mammalian spinal closure.
Journal ArticleDOI
Regulation of cell protrusions by small GTPases during fusion of the neural folds
Ana Rolo,Dawn Savery,Sarah Escuin,Sandra C. P. De Castro,Hannah E. J. Armer,Peter M. G. Munro,Matteo A. Molè,Nicholas D. E. Greene,Andrew J. Copp +8 more
TL;DR: Evidence is provided for the essential role and molecular regulation of membrane protrusions prior to fusion of a key organ primordium in mammalian development by genetically ablating the cytoskeletal regulators Rac1 or Cdc42.
Journal ArticleDOI
Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids
Thomas M Rawlings,Komal Makwana,Deborah M. Taylor,Deborah M. Taylor,Matteo A. Molè,Katherine J. Fishwick,Maria Tryfonos,Joshua Odendaal,Joshua Odendaal,Amelia Hawkes,Amelia Hawkes,Magdalena Zernicka-Goetz,Magdalena Zernicka-Goetz,Geraldine M. Hartshorne,Geraldine M. Hartshorne,Jan J. Brosens,Jan J. Brosens,Emma S. Lucas +17 more
TL;DR: In this paper, single-cell transcriptomics revealed that decidualized assembloids closely resemble midluteal endometrium, harboring differentiated and senescent subpopulations in both glands and stroma.
Journal ArticleDOI
Cellular basis of neuroepithelial bending during mouse spinal neural tube closure
Suzanne G. McShane,Matteo A. Molè,Dawn Savery,Nicholas D. E. Greene,Patrick P.L. Tam,Andrew J. Copp +5 more
TL;DR: Findings suggest a model in which DLHP formation may proceed through ‘buckling’ of the neuroepithelium at a dorso-ventral boundary marked by a change in cell-packing density.
Book ChapterDOI
Comparative analysis of human and mouse development: From zygote to pre-gastrulation
TL;DR: Current knowledge of mammalian development of both mouse and human is reviewed, focusing on morphogenetic processes leading to the onset of gastrulation, when the embryonic anterior-posterior axis becomes established and the three germ layers start to be specified.