Matteo Jacopo Marzi

TL;DR: A test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non‐small cell lung carcinomas (NSCLCs) in a population of asymptomatic high‐risk individuals with 80% accuracy is developed.

TL;DR: It is argued that the miR-Test might represent a useful tool for lung cancer screening in high-risk individuals by clearly defining the target "high-risk" population that needs to be screened by LDCT.

TL;DR: A pulse-chase approach based on metabolic RNA labeling was developed to calculate miRNA decay rates at genome-wide scale in mammalian cells, highlighting functional mechanisms that mediate miRNA degradation, as well as the importance of decay dynamics in the regulation of the miRNA pool under both steady-state conditions and during cell transitions.

TL;DR: Serpine1 mRNA is shown as one such RNA that can control the levels of the endogenous miRNA miR-30b/c-5p by modulating miRNA degradation via the target-directed miRNAs degradation process.

TL;DR: This methodology provided a 40% increase in the number of detected miRNA species and allowed to easily identify and classify more than 1000 variants and could be used to explore the functional role of miRNA isoforms.