Showing papers by "Matthew B. Grisham published in 1978"

TL;DR: The mechanism that leads to an inhibition of enzyme activity in the presence of high concentrations of substrate was investigated with the two malate dehydrogenase isoenzymes obtained from pig heart, and it is suggested that the substrate inhibition that is exhibited by the malate dehydrationases may not be of any significance in vivo.

TL;DR: The use of standard curves of percent inhibition of malate dehydrogenase activity plotted against the ratio of mitochondrial MDH activity to the total of mMDH and cMDH activities is introduced for studies of comparative mitochondrial function in heart muscle of different species or in different tissues of the same species.