M
Matthew D. Troutman
Researcher at Pfizer
Publications - 26
Citations - 2687
Matthew D. Troutman is an academic researcher from Pfizer. The author has contributed to research in topics: P-glycoprotein & Acoustic droplet ejection. The author has an hindex of 17, co-authored 26 publications receiving 2351 citations.
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Journal ArticleDOI
The impact of p-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the mdr1a/ 1b knockout mouse model
Angela C. Doran,R. Scott Obach,Bill J. Smith,Natilie Hosea,Stacey L. Becker,Ernesto Callegari,Cuiping Chen,Xi Chen,Edna F. Choo,Julie Cianfrogna,Loretta M. Cox,John P. Gibbs,Megan A. Gibbs,Heather L. Hatch,Cornelis E. C. A. Hop,Ilana N. Kasman,Jennifer L. LaPerle,JianHua Liu,Xingrong Liu,Michael J. Logman,Debra Maclin,Frank M. Nedza,Frederick R. Nelson,Emily R. Olson,Sandhya Rahematpura,David Raunig,Sabrinia Rogers,Kari Schmidt,Douglas K. Spracklin,Mark A. Szewc,Matthew D. Troutman,Elaine E. Tseng,Meihua Tu,Jeffrey Van Deusen,Karthik Venkatakrishnan,Gary Walens,Ellen Q. Wang,Diane Wong,Adam Yasgar,Chenghong Zhang +39 more
TL;DR: It appears that most CNS-active agents demonstrate at least some P-gp-mediated transport that can affect brain concentrations, and unbound plasma concentrations may need to be greater than values projected using receptor affinity data to achieve adequate receptor occupancy for effect.
Journal ArticleDOI
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.
Bo Feng,Jessica B. Mills,Ralph E. Davidson,Rouchelle J. Mireles,John S. Janiszewski,Matthew D. Troutman,Sonia M. de Morais +6 more
TL;DR: It is demonstrated that in vitro transporter assays help in understanding the role of P-glycoprotein-mediated efflux activity in determining the disposition of CNS drugs in vivo, and the transwell assay is a valuable in vitro assay to evaluate human P-gp interaction with compounds for assessing brain penetration of new chemical entities to treat CNS disorders.
Journal ArticleDOI
Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
Travis T. Wager,Ramalakshmi Yegna Chandrasekaran,Xinjun Hou,Matthew D. Troutman,Patrick Robert Verhoest,Anabella Villalobos,Yvonne Will +6 more
TL;DR: A thorough analysis of properties for 119 marketed CNS drugs and a set of 108 Pfizer CNS candidates focused on understanding the relationships between physicochemical properties, in vitro ADME attributes, primary pharmacology binding efficiencies, and in vitro safety data.
Journal ArticleDOI
Development of a new permeability assay using low-efflux MDCKII cells
Li Di,Carrie Whitney-Pickett,John P. Umland,Hui Zhang,Xun Zhang,David F. Gebhard,Yurong Lai,James Federico,Ralph E. Davidson,Russ Smith,Eric L. Reyner,Caroline A. Lee,Bo Feng,Charles J. Rotter,Manthena V.S. Varma,Sarah Kempshall,Katherine S. Fenner,Ayman El-Kattan,Theodore E. Liston,Matthew D. Troutman +19 more
TL;DR: A new cell line, MDCKII-LE (low efflux), has been developed by selecting a subpopulation of low-efflux cells from MDCkII-WT using an iterative fluorescence-activated cell sorting technique with calcein-AM as a Pgp and efflux substrate.
Journal ArticleDOI
Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination
Manthena V.S. Varma,R. Scott Obach,Charles J. Rotter,Howard Miller,George Chang,Stefanus J. Steyn,Ayman El-Kattan,Matthew D. Troutman +7 more
TL;DR: In conclusion, physicochemical properties influence bioavailability with typically opposing effects on Fa and first-pass elimination, which may provide a rational judgment on the physicochemical space to optimize oral bioavailability.