M
Matthew G. Annis
Researcher at McGill University
Publications - 44
Citations - 3097
Matthew G. Annis is an academic researcher from McGill University. The author has contributed to research in topics: Metastasis & Breast cancer. The author has an hindex of 23, co-authored 38 publications receiving 2594 citations. Previous affiliations of Matthew G. Annis include National Research Council & McMaster University Medical Centre.
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Journal ArticleDOI
PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer
Fanny Dupuy,Sébastien Tabariès,Sylvia Andrzejewski,Zhifeng Dong,Julianna Blagih,Matthew G. Annis,Atilla Omeroglu,Dongxia Gao,Samuel Leung,Eitan Amir,Mark Clemons,Adriana Aguilar-Mahecha,Mark Basik,Emma E. Vincent,Julie St-Pierre,Russell G. Jones,Peter M. Siegel +16 more
TL;DR: It is demonstrated that PDK1 is required for efficient liver metastasis, and its expression is elevated in liver metastases from breast cancer patients, and the data implicatePDK1 as a key regulator of metabolism and metastatic potential in breast cancer.
Journal ArticleDOI
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
Matthew G. Annis,Erinn L. Soucie,Paulina J Dlugosz,Jorge A. Cruz-Aguado,Linda Z. Penn,Brian Leber,David W. Andrews +6 more
TL;DR: The results suggest that unlike most pore‐forming proteins, Bax membrane permeabilization results from oligomerization of transmembrane monomers rather than concerted insertion of the pore domains of a preformed oligomer.
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Bcl-2 changes conformation to inhibit Bax oligomerization
Paulina J Dlugosz,Lieven P. Billen,Matthew G. Annis,Weijia Zhu,Zhi Zhang,Jialing Lin,Brian Leber,David W. Andrews +7 more
TL;DR: Bcl‐2 functions as an inhibitor of mitochondrial permeabilization by changing conformation in the mitochondrial membrane to bind membrane‐inserted Bax monomers and prevent productive oligomerization of Bax.
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PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs.
Sylvia Andrzejewski,Eva Klimcakova,Radia M. Johnson,Sébastien Tabariès,Matthew G. Annis,Shawn McGuirk,Jason J. Northey,Valérie Chénard,Urshila Sriram,David Papadopoli,Peter M. Siegel,Julie St-Pierre +11 more
TL;DR: It is revealed that breast cancer cells that preferentially metastasize to the lung or bone display relatively high expression of PGC-1α compared with those that metastasized to the liver.
Journal ArticleDOI
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.
April A.N. Rose,Matthew G. Annis,Zhifeng Dong,Francois Pepin,Michael Hallett,Morag Park,Peter M. Siegel +6 more
TL;DR: Ectodomain shedding may serve as a novel mechanism by which GPNMB/OA promotes angiogenesis in breast cancer.