Matthew Hedge

TL;DR: This is the first reported death for methylone or butylone and the first human or animal ingestion ofbutylone.

TL;DR: In this article, the salivary content of these enzymes was found to be increased upon daily consumption of relatively large amounts of coffee or broccoli, indicating that these enzymes are abundantly present in the human diet, especially in certain vegetables and fruits.

TL;DR: The results obtained from this investigation are consistent with previous studies which show that aromatase has a hydrophobic pocket in the active site around the C-4 alpha region of androstenedione, and that the free pair of electrons on N, S, or O is not an essential requirement for 4-substituted androstensione derivatives to be effective aromat enzyme inhibitors.

TL;DR: The synthesis and biological evaluation of 4-thiosubstituted derivatives of 1,4-androstadienedione, 4,6-and Frostenedione, and 1,8-androstatrienedione as inhibitors of aromatase were described and were found to be competitive inhibitors and did not produce any time-dependent inactivation of arom atase.

TL;DR: Three classes of therapeutic drugs are focused on, with specific examples in which overdoses require admission to the intensive care unit, including the newer antidepressants, the atypical neuroleptic agents, and selected anticonvulsant drugs.