M
Matthew Iyobhebhe
Researcher at Landmark University
Publications - 21
Citations - 100
Matthew Iyobhebhe is an academic researcher from Landmark University. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 2, co-authored 5 publications receiving 8 citations.
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Journal ArticleDOI
Deciphering the Interactions of Bioactive Compounds in Selected Traditional Medicinal Plants against Alzheimer's Diseases via Pharmacophore Modeling, Auto-QSAR, and Molecular Docking Approaches.
Oluwafemi Adeleke Ojo,Adebola Busola Ojo,Charles E. Okolie,Mary-Ann Chinyere Nwakama,Matthew Iyobhebhe,Ikponmwosa Owen Evbuomwan,Charles Obiora Nwonuma,Rotdelmwa Filibus Maimako,Abayomi Emmanuel Adegboyega,Odunayo Anthonia Taiwo,Khalaf F. Alsharif,Gaber El-Saber Batiha +11 more
TL;DR: In this article, the authors evaluated nine flavonoid compounds identified from three medicinal plants, namely T. diversifolia, B. sapida, and I. gabonensis for their inhibitory role on acetylcholinesterase (AChE), butyrylcholine-choline (BChE) and monoamine oxidase (MAO) activity, using pharmacophore modeling, auto-QSAR prediction, and molecular studies.
Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway
Oluwafemi Adeleke Ojo,J. Amanze,A. I. Oni,Susan C.H Grant,Matthew Iyobhebhe,Tobiloba Christiana Elebiyo,Damilare Rotimi,Nnaemeka Tobechukwu Asogwa,Babatunji Emmanuel Oyinloye,Basiru Olaitan Ajiboye,Adebola Busola Ojo +10 more
TL;DR: Administration of Persea americana seeds can promote the activation of the PI3K/AkT pathway and the inhibition of β-cell death, which may be the primary mechanism by which AEPAS promotes insulin sensitivity and regulates glycolipid metabolism.
Journal ArticleDOI
Anticancer Properties of Curcumin Against Colorectal Cancer: A Review
Oluwafemi Adeleke Ojo,Temiloluwa Rhoda Adeyemo,Damilare Rotimi,Gaber El-Saber Batiha,Gomaa Mostafa-Hedeab,Matthew Iyobhebhe,Tobiloba Christiana Elebiyo,Bukola Atunwa,Adebola Busola Ojo,Clara Mariana Gonçalves Lima,Carlos Adam Conte-Junior +10 more
TL;DR: Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC and the critical role of these substances in CRC chemoprevention was emphasized.
Journal ArticleDOI
Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats
Oluwafemi Adeleke Ojo,A. I. Oni,Susan C.H Grant,J. Amanze,Adebola Busola Ojo,Odunayo Anthonia Taiwo,Rotdelmwa Filibus Maimako,Ikponmwosa Owen Evbuomwan,Matthew Iyobhebhe,Charles Obiora Nwonuma,O. O. Osemwegie,A.O Agboola,C.O Akintayo,Nnaemeka Tobechukwu Asogwa,Nada H. Aljarba,Saad Alkahtani,Gomaa Mostafa-Hedeab,Gaber El-Saber Batiha,Oluyomi Stephen Adeyemi +18 more
TL;DR: This in vitro study showed inhibitory potency of Cenchrus purpureus extract (AECPS) as compared with the positive controls, and showed efficient ameliorative actions against alloxan-induced pancreatic dysfunction, oxidative stress suppression as well as, inflammation, and apoptosis via the activation of PI3K/AKT signaling pathways.
Journal ArticleDOI
Exploring the potentials of some compounds from Garcinia kola seeds towards identification of novel PDE-5 inhibitors in erectile dysfunction therapy.
Oluwafemi Adeleke Ojo,Adebola Busola Ojo,Rotdelmwa Filibus Maimako,Damilare Rotimi,Matthew Iyobhebhe,Omokolade Oluwaseyi Alejolowo,Charles Obiora Nwonuma,Tobiloba Christaina Elebiyo +7 more
TL;DR: In this article, the molecular relations obtainable between catechin, garcinal, garcininal acid and d-tocotrienol compounds isolated from Garcinia kola and a targeted receptor linked to ED were assessed.