Matthew J. Ravosa

TL;DR: Functional variability across autopods, substrate and species that could underlie morphological variation within and across primates is observed and the complexity of arboreality should be considered when inferring locomotor modes in fossils.

TL;DR: The ontogeny of orbital convergence and frontation in 13 anthropoid and strepsirrhine species was characterized and interspecific variation in relative levels of frontation was linked to corresponding ontogenetic transpositions in encephalization that differed within both suborders.

TL;DR: A new role for ascites-induced compression is elucidated in promoting metastatic OvCa progression using a panel of in vitro, ex vivo and in vivo assays, and peritoneal collagen fibers adopted a more linear anisotropic alignment under compression, a collagen signature commonly correlated with enhanced invasion in solid tumors.

TL;DR: Development of new in vitro model systems with which to evaluate cellular responses to compression enables experimental modeling of the intraperitoneal force environment of ovarian cancer patients with tense ascites.

TL;DR: Results show that ILK is co-expressed in EOC with the pro-metastatic enzyme membrane type 1 matrix metalloproteinase (MT1-MMP) and catalyzed phosphorylation of the cytoplasmic tail of the proteinase and downregulation of ILK expression or activity reduced adhesion to and invasion of collagen gels and organotypic meso-mimetic cultures.