Matthew P. Salomon

TL;DR: A 'Big Bang' model is presented, whereby tumors grow predominantly as a single expansion producing numerous intermixed subclones that are not subject to stringent selection and where both public and most detectable private alterations arise early during growth.

TL;DR: Drosophila melanogaster is developed as a model for sex-specific stress adaptation regulated by the Lon protease, with potential implications for understanding sexual dimorphism in human disease.

TL;DR: Novel insights are revealed into the epigenomics underlying pituitary adenomas and how differences in epigenomic states are related to important transcriptome alterations that define adenoma subtypes are highlighted.

TL;DR: The genomic analysis of D. melanogaster populations from the south‐east US and Caribbean Islands provides more evidence for the Caribbean Islands as the source of previously reported novel African alleles found in other east coast US populations, and finds the border between the South East US and the Caribbean island to be the admixture hot zone where distinctly African‐like Caribbean flies become genomically more similar to European‐like south‐East US flies.

TL;DR: The authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.