J
Javier I. J. Orozco
Researcher at National University of Cuyo
Publications - 34
Citations - 392
Javier I. J. Orozco is an academic researcher from National University of Cuyo. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 10, co-authored 22 publications receiving 275 citations. Previous affiliations of Javier I. J. Orozco include St. John's University.
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Journal ArticleDOI
Epigenetic profiling for the molecular classification of metastatic brain tumors.
Javier I. J. Orozco,Theo A. Knijnenburg,Ayla O. Manughian-Peter,Matthew P. Salomon,Garni Barkhoudarian,John R. Jalas,James S. Wilmott,Parvinder Hothi,Xiaowen Wang,Yuki Takasumi,Michael E. Buckland,John F. Thompson,Georgina V. Long,Georgina V. Long,Charles Cobbs,Ilya Shmulevich,Daniel F. Kelly,Richard A. Scolyer,Richard A. Scolyer,Dave S.B. Hoon,Diego M. Marzese +20 more
TL;DR: The authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.
Journal ArticleDOI
Methylation profile of triple-negative breast carcinomas
Maria Teresita Branham,Diego M. Marzese,Sergio Laurito,Francisco E. Gago,Javier I. J. Orozco,Olga Tello,Laura M. Vargas-Roig,Laura M. Vargas-Roig,María Roqué +8 more
TL;DR: This study analyzes the hypermethylation of 110 CpGI within 69 cancer-related genes in triple-negative breast tumors to conclude that TN tumors have a specific methylation profile.
Journal ArticleDOI
DNA methylation index and methylation profile of invasive ductal breast tumors.
Diego M. Marzese,Diego M. Marzese,Dave S.B. Hoon,Kelly Chong,Francisco E. Gago,Javier I. J. Orozco,Olga Tello,Laura M. Vargas-Roig,Laura M. Vargas-Roig,María Roqué,María Roqué +10 more
TL;DR: The results indicate that methylation index and methylation of TP73 and/or RARB are related to unfavorable prognostic factors in patients with IDC and should be validated in further studies to improve breast cancer management.
Journal ArticleDOI
The metastatic microenvironment: Melanoma–microglia cross‐talk promotes the malignant phenotype of melanoma cells
Sivan Izraely,Shlomit Ben-Menachem,Orit Sagi-Assif,Alona Telerman,Inna Zubrilov,Ofir Ashkenazi,Tsipi Meshel,Shelly Maman,Javier I. J. Orozco,Matthew P. Salomon,Diego M. Marzese,Metsada Pasmanik-Chor,Eli Pikarski,Marcelo Ehrlich,Dave S.B. Hoon,Isaac P. Witz +15 more
TL;DR: A novel insight is provided into the bidirectional interactions between melanoma and micoglia cells, suggesting the contribution of microglia to melanoma brain metastasis formation.
Journal ArticleDOI
Alternative splicing and cancer metastasis: prognostic and therapeutic applications.
TL;DR: In insights about the genomic and epigenomic factors affecting AS are presented, the most recent findings linking aberrant AS to metastatic progression are summarized, and potential prognostic and therapeutic applications are highlighted.