M
Matthew Powers
Researcher at University of Florida
Publications - 4
Citations - 267
Matthew Powers is an academic researcher from University of Florida. The author has contributed to research in topics: Genetic enhancement & Islet. The author has an hindex of 4, co-authored 4 publications receiving 259 citations.
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Journal ArticleDOI
Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations In Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-Dependent Fashion
Kevin Goudy,Brant R. Burkhardt,Clive Wasserfall,Sihong Song,Martha Campbell-Thompson,Todd M. Brusko,Matthew Powers,Michael J. Clare-Salzler,Eric S. Sobel,Tamir M. Ellis,Terence R. Flotte,Mark A. Atkinson +11 more
TL;DR: The potential for immunomodulatory gene therapy to prevent autoimmune diseases, including type 1 diabetes, is indicated, and IL-10 is implicates as a molecule capable of increasing the percentages of regulatory cells in vivo.
Journal ArticleDOI
Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice
Y. Clare Zhang,Antonello Pileggi,Anupam Agarwal,R. Damaris Molano,Matthew Powers,Todd M. Brusko,Clive Wasserfall,Kevin Goudy,E. Zahr,Raffaella Poggioli,Marda Scott-Jorgensen,Martha Campbell-Thompson,James M. Crawford,Harry S. Nick,Terence R. Flotte,Tamir M. Ellis,Camillo Ricordi,Luca Inverardi,Mark A. Atkinson +18 more
TL;DR: These studies support the utility of immunoregulatory cytokine gene therapy delivered by rAAV for preventing autoimmune disease recurrence in transplant-based therapies for type 1 diabetes.
Journal ArticleDOI
Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity.
Ying Zhang,Matthew Powers,Clive Wasserfall,Todd M. Brusko,Sihong Song,Terence R. Flotte,Richard O. Snyder,Mark Potter,Marda Scott-Jorgensen,Martha Campbell-Thompson,James M. Crawford,Harry S. Nick,Anupam Agarwal,Tamir M. Ellis,Mark A. Atkinson +14 more
TL;DR: It is found that earlier studies underappreciated the degree of AAV immunogenicity as well as the extent to which genetic background, through regulation of immune responsiveness, influences the duration of gene expression and thereby the effectiveness of A AV-mediated gene therapy.
Journal ArticleDOI
Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation.
Y. Clare Zhang,R. Damaris Molano,Antonello Pileggi,Matthew Powers,Jeffrey Cross,Clive Wasserfall,Marda Scott-Jorgensen,Martha Campbell-Thompson,James M. Crawford,Terence R. Flotte,Tamir M. Ellis,Camillo Ricordi,Mark A. Atkinson,Luca Inverardi +13 more
TL;DR: Islet expression of IL-4 led to impaired metabolic function in mice receiving a marginal mass of syngeneic islets, which was not associated with cellular toxicity of rAAV or impairment of glucose-stimulated insulin release in vitro.