M
Matthew R. Pratt
Researcher at University of Southern California
Publications - 97
Citations - 3568
Matthew R. Pratt is an academic researcher from University of Southern California. The author has contributed to research in topics: Glycosylation & Glycoprotein. The author has an hindex of 33, co-authored 88 publications receiving 2886 citations. Previous affiliations of Matthew R. Pratt include Rockefeller University & University of Arizona.
Papers
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Synthetic glycopeptides and glycoproteins as tools for biology.
TL;DR: This tutorial review focuses on recent applications of homogeneous synthetic glycopeptides and glycoproteins for studies of structure and function in protein glycosylation.
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Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1
TL;DR: Using in-gel fluorescence detection, the development of an alkynyl-modified GlcNAc analog (GlcNAlk) is described as a new chemical reporter of O-GlcNAC modification in living cells based on metabolic incorporation of reactive functionality into the Glc NAc biosynthetic pathway.
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O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease
Nicholas P. Marotta,Yu Hsuan Lin,Yuka E. Lewis,Mark R. Ambroso,Balyn W. Zaro,Maxwell Taylor Roth,Don B. Arnold,Ralf Langen,Matthew R. Pratt +8 more
TL;DR: It is suggested that increasing O-GlcNAcylation may slow the progression of synucleinopathies and further support a general function for O- GlcNAc in preventing protein aggregation.
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Click Chemistry in Proteomic Investigations
TL;DR: This Primer discusses how one of the most versatile bioorthogonal reactions, "click chemistry", has been exploited to overcome limitations of biological approaches to enable the selective marking and functional investigation of critical protein-small-molecule interactions and PTMs in native biological environments.
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Homogeneous glycopeptides and glycoproteins for biological investigation.
TL;DR: This review summarizes current efforts to obtain homogeneous glycopeptide and glycoprotein materials by a variety of methods that draw from the techniques of recombinant expression, chemical synthesis, enzymatic transformation, and chemoselective ligation.