Matthew T. Wolf

TL;DR: There is a strong correlation between the early macrophage response to implanted materials and the outcome of tissue remodeling and the results of the present study suggest that the constructive remodeling outcome may be due to the recruitment and survival of different cell populations to the sites of remodeling associated with materials that elicit an M1 vs. M2 response.

TL;DR: It is investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration and Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

TL;DR: It is concluded that processing steps evaluated in the present study affect content, mechanical strength, and/or cytocompatibility of the resultant porcine dermal ECM, and therefore care must be taken in choosing appropriate processing steps to maintain the beneficial effects of ECM in biologic scaffolds.

TL;DR: This paper showed similarities in the remodeling characteristics of xenogeneic extracellular matrix (ECM) scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients.

TL;DR: Results show that ECM hydrogel properties can be varied and partially controlled by the scaffold tissue source, and that these properties can markedly affect cell behavior.