Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials.
Bryan N. Brown,Ricardo Londono,Stephen Tottey,Li Zhang,Kathryn A. Kukla,Matthew T. Wolf,Kerry A. Daly,Janet E. Reing,Stephen F. Badylak +8 more
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TLDR
There is a strong correlation between the early macrophage response to implanted materials and the outcome of tissue remodeling and the results of the present study suggest that the constructive remodeling outcome may be due to the recruitment and survival of different cell populations to the sites of remodeling associated with materials that elicit an M1 vs. M2 response.About:
This article is published in Acta Biomaterialia.The article was published on 2012-03-01 and is currently open access. It has received 649 citations till now. The article focuses on the topics: Macrophage polarization.read more
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Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine.
TL;DR: The diverse roles played by macrophages in these processes are discussed in addition to the potential manipulation of macrophage effector mechanisms as a strategy for promoting site-appropriate and constructive tissue remodeling as opposed to deleterious persistent inflammation and scar tissue formation.
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Biomaterial based modulation of macrophage polarization: A review and suggested design principles
Rukmani Sridharan,Rukmani Sridharan,Andrew R. Cameron,Andrew R. Cameron,Daniel J. Kelly,Cathal J. Kearney,Fergal J. O'Brien,Fergal J. O'Brien +7 more
TL;DR: An in depth understanding of biomaterial cues to selectively polarize macrophages may prove beneficial in the design of a new generation of ‘immuno-informed’ biomaterials that can positively interact with the immune system to dictate a favorable macrophage response following implantation.
Journal ArticleDOI
Macrophage M1/M2 polarization.
TL;DR: The mechanism of macrophage polarization from the tumor microenvironment, nanocarriers, nuclear receptor PPARγ, phagocytosis, NF-κB signaling pathways, and other pathways is analyzed.
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The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development
Anna Sorushanova,Luis Delgado,Z Wu,Naledi Shologu,Aniket Kshirsagar,Rufus Raghunath,Anne Maria Mullen,Yves Bayon,Abhay Pandit,Michael Raghunath,Dimitrios I. Zeugolis +10 more
TL;DR: How advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules is reviewed.
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Extracellular matrix-based materials for regenerative medicine
TL;DR: Challenges and opportunities of ECM biomaterials are investigated for the design of organotypic models to study disease progression, for the ex vivo creation of engineered tissue and for the clinical translation of functional tissue reconstruction strategies in vivo.
References
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The chemokine system in diverse forms of macrophage activation and polarization.
Alberto Mantovani,Alberto Mantovani,Antonio Sica,Silvano Sozzani,Silvano Sozzani,Paola Allavena,Annunciata Vecchi,Massimo Locati +7 more
TL;DR: Recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.
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Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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M-1/M-2 macrophages and the Th1/Th2 paradigm.
TL;DR: The results indicate that M-1- or M-2-dominant macrophage responses can influence whether Th1/Th2 or other types of inflammatory responses occur.
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Sterile inflammation: sensing and reacting to damage
Grace Y. Chen,Gabriel Núñez +1 more
TL;DR: The triggers and receptor pathways that result in sterile inflammation and its impact on human health are reviewed.
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Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression
TL;DR: Transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology.