M
Matthias Frommhagen
Researcher at Wageningen University and Research Centre
Publications - 19
Citations - 706
Matthias Frommhagen is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Myceliophthora thermophila & Cellulose. The author has an hindex of 10, co-authored 17 publications receiving 521 citations. Previous affiliations of Matthias Frommhagen include Martin Luther University of Halle-Wittenberg.
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Journal ArticleDOI
Discovery of the combined oxidative cleavage of plant xylan and cellulose by a new fungal polysaccharide monooxygenase
Matthias Frommhagen,Stefano Sforza,Stefano Sforza,Adrie H. Westphal,Jaap Visser,Sandra W.A. Hinz,Martijn J. Koetsier,Willem J. H. van Berkel,Harry Gruppen,Mirjam A. Kabel +9 more
TL;DR: The ability of MtLPMO9A to cleave these rigid regions provides a new paradigm in the understanding of the degradation of xylan-coated cellulose, and provides new insights into how to boost plant biomass degradation by enzyme cocktails for biorefinery applications.
Journal ArticleDOI
Lytic polysaccharide monooxygenases from Myceliophthora thermophila C1 differ in substrate preference and reducing agent specificity.
Matthias Frommhagen,Martijn J. Koetsier,Adrie H. Westphal,Jaap Visser,Sandra W.A. Hinz,Jean-Paul Vincken,Willem J. H. van Berkel,Mirjam A. Kabel,Harry Gruppen +8 more
TL;DR: The hypothesis that the activity of LPMOs toward lignocellulosic biomass does not only depend on the ability to degrade plant polysaccharides like cellulose, but also on their specificity toward plant-derived reducing agents in situ is supported.
Journal ArticleDOI
Distinct Substrate Specificities and Electron-Donating Systems of Fungal Lytic Polysaccharide Monooxygenases
TL;DR: A closer look at LPMOs as part of the fungal enzyme machinery might provide insights into their role in fungal growth and plant-pathogen interactions to further stimulate the search for novel LPMO applications.
Journal ArticleDOI
Boosting LPMO-driven lignocellulose degradation by polyphenol oxidase-activated lignin building blocks
Matthias Frommhagen,Sumanth K. Mutte,Adrie H. Westphal,Martijn J. Koetsier,Sandra W.A. Hinz,Jaap Visser,Jean-Paul Vincken,Dolf Weijers,Willem J. H. van Berkel,Harry Gruppen,Mirjam A. Kabel +10 more
TL;DR: An up to 75-fold improvement in LPMO-driven cellulose degradation using polyphenol oxidase-activated lignin building blocks is shown and the activity towards methoxylated phenolic compounds distinguishes MtPPO7 from well-known PPOs, and ensures that Mt PPO7 is an excellent redox partner of LPMOs.
Journal ArticleDOI
Quantification of the catalytic performance of C1-cellulose-specific lytic polysaccharide monooxygenases
Matthias Frommhagen,Adrie H. Westphal,Roelant Hilgers,Martijn J. Koetsier,Sandra W.A. Hinz,Jaap Visser,Harry Gruppen,Willem J. H. van Berkel,Mirjam A. Kabel +8 more
TL;DR: The development of a β-glucosidase-assisted method to quantify the release of C1-oxidized gluco-oligosaccharides from cellulose by two LPMOs from Myceliophthora thermophila C1 demonstrates that the catalytic performance of both MtLPMOs is strongly dependent on pH and temperature.