M
Mattia Cinelli
Researcher at Weizmann Institute of Science
Publications - 7
Citations - 216
Mattia Cinelli is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: T-cell receptor & Antigen. The author has an hindex of 4, co-authored 5 publications receiving 171 citations.
Papers
More filters
Journal ArticleDOI
Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence
Niclas Thomas,Katharine Best,Mattia Cinelli,Shlomit Reich-Zeliger,Hilah Gal,Eric Shifrut,Asaf Madi,Nir Friedman,John Shawe-Taylor,Benny Chain +9 more
TL;DR: The results reinforce the remarkable diversity of the TcR repertoire, resulting in many diverse private TcRs contributing to the T-cell response even in genetically identical mice responding to the same antigen.
Journal ArticleDOI
Feature selection using a one dimensional naïve Bayes’ classifier increases the accuracy of support vector machine classification of CDR3 repertoires
Mattia Cinelli,Yuxin Sun,Katharine Best,James M. Heather,Shlomit Reich-Zeliger,Eric Shifrut,Nir Friedman,John Shawe-Taylor,Benny Chain +8 more
TL;DR: Using this approach, it is demonstrated that the frequency of a small number of linear motifs three amino acids in length can accurately identify a CD4 T cell response to ovalbumin against a background response to the complex mixture of antigens which characterize Complete Freund's Adjuvant.
Journal ArticleDOI
Specificity, Privacy, and Degeneracy in the CD4 T Cell Receptor Repertoire Following Immunization.
Yuxin Sun,Katharine Best,Mattia Cinelli,James M. Heather,Shlomit Reich-Zeliger,Eric Shifrut,Nir Friedman,John Shawe-Taylor,Benny Chain +8 more
TL;DR: High-throughput sequencing is applied to investigate the global changes in T cell receptor sequences following immunization with ovalbumin (OVA) and adjuvant, to understand how adaptive immunity achieves specificity.
Posted ContentDOI
Tracking global changes induced in the CD4 T cell receptor repertoire by immunisation with a complex antigen using local sequence features of CDR3 protein sequence
Niclas Thomas,Mattia Cinelli,Shlomit Reich-Zeliger,Hilah Gal,Eric Shifrut,Asaf Madi,Nir Friedman,John Shawe-Taylor +7 more
TL;DR: This study measures the frequency of different TcRs in CD4+ T cell populations of mice immunized with a complex antigen, killed Mycobacterium tuberculosis, using high throughput parallel sequencing of the TcR beta chain to provide new insights into the properties of the CD4+.
Posted ContentDOI
Tracking global changes induced in the CD4 T cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence.
Niclas Thomas,Katharine Best,Mattia Cinelli,Shlomit Reich-Zeliger,Hilah Gal,Eric Shifrut,Asaf Madi,Nir Friedman,John Shawe-Taylor,Benny Chain +9 more
TL;DR: In this article, the frequency of different TcRs in CD4+ T cell populations of mice immunized with a complex antigen, killed Mycobacterium tuberculosis, using high throughput parallel sequencing of the TcR beta chain.