E
Eric Shifrut
Researcher at University of California, Berkeley
Publications - 48
Citations - 3178
Eric Shifrut is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 19, co-authored 39 publications receiving 1887 citations. Previous affiliations of Eric Shifrut include University of California, San Francisco & Gladstone Institutes.
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Journal ArticleDOI
Reprogramming human T cell function and specificity with non-viral genome targeting
Theodore L. Roth,Cristina Puig-Saus,Ruby Yu,Ruby Yu,Eric Shifrut,Eric Shifrut,Julia Carnevale,P. Jonathan Li,P. Jonathan Li,Joseph Hiatt,Justin Saco,Paige Krystofinski,Han Li,Victoria Tobin,Victoria Tobin,David N. Nguyen,David N. Nguyen,Michael R. Lee,Amy L. Putnam,Andrea L. Ferris,Jeff W. Chen,Jean Nicolas Schickel,Laurence Pellerin,David Carmody,Gorka Alkorta-Aranburu,Daniela del Gaudio,Hiroyuki Matsumoto,Montse Morell,Ying Mao,Min Cho,Rolen M. Quadros,Channabasavaiah B. Gurumurthy,Baz Smith,Michael Haugwitz,Stephen H. Hughes,Jonathan S. Weissman,Kathrin Schumann,Kathrin Schumann,Jonathan H. Esensten,Andrew P. May,Alan Ashworth,Gary M. Kupfer,Siri Atma W. Greeley,Rosa Bacchetta,Eric Meffre,Maria Grazia Roncarolo,Neil Romberg,Neil Romberg,Kevan C. Herold,Antoni Ribas,Manuel D. Leonetti,Alexander Marson +51 more
TL;DR: A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.
Journal ArticleDOI
Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
Eric Shifrut,Eric Shifrut,Julia Carnevale,Victoria Tobin,Victoria Tobin,Theodore L. Roth,Theodore L. Roth,Jonathan M. Woo,Jonathan M. Woo,Christina Bui,P. Jonathan Li,P. Jonathan Li,Morgan E. Diolaiti,Alan Ashworth,Alexander Marson +14 more
TL;DR: A new method, single guide RNA (sgRNA) lentiviral infection with Cas9 protein electroporation (SLICE) with single-cell RNA sequencing (RNA-seq) revealed signature stimulation-response gene programs altered by key genetic perturbations in primary human T cells.
Journal ArticleDOI
McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences.
TL;DR: The McPAS‐TCR database currently contains more than 5000 sequences of TCRs associated with various pathologic conditions and their respective antigens in humans and in mice and provides interesting insights on pathology‐associated TCR sequences.
Journal ArticleDOI
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
Kuti Baruch,Noga Ron-Harel,Hilah Gal,Aleksandra Deczkowska,Eric Shifrut,Wilfred Ndifon,Nataly Mirlas-Neisberg,Michal Cardon,Ilan Vaknin,Liora Cahalon,Tamara Berkutzki,Mark P. Mattson,Fernando Gomez-Pinilla,Nir Friedman,Michal Schwartz +14 more
TL;DR: The data indicate that the cytokine milieu at the CP epithelium is affected by peripheral immunosenescence, with detrimental consequences to the aged brain, and this interface is a unique target for arresting age-related cognitive decline.
Journal ArticleDOI
T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity
Asaf Madi,Eric Shifrut,Shlomit Reich-Zeliger,Hilah Gal,Katharine Best,Wilfred Ndifon,Benjamin M. Chain,Irun R. Cohen,Nir Friedman +8 more
TL;DR: It is suggested that biases and convergence in TCR recombination combine with ongoing selection to generate a restricted subset of self-associated, public CDR3 TCR sequences, and invite reexamination of the basic mechanisms of T-cell repertoire formation.