Katharine Best

TL;DR: It is shown that both rhesus and cynomolgus macaques are highly susceptible to infection by lineages of Zika virus that are closely related to, or are currently circulating in, the Americas.

TL;DR: It is suggested that biases and convergence in TCR recombination combine with ongoing selection to generate a restricted subset of self-associated, public CDR3 TCR sequences, and invite reexamination of the basic mechanisms of T-cell repertoire formation.

TL;DR: It is shown that ZikV can persist in cerebrospinal fluid (CSF) and lymph nodes of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions, raising the possibility that persistent or occult neurologic and lymphoid disease may occur following clearance of peripheral virus in ZIKV-infected individuals.

TL;DR: The results reinforce the remarkable diversity of the TcR repertoire, resulting in many diverse private TcRs contributing to the T-cell response even in genetically identical mice responding to the same antigen.

TL;DR: In this article, a protocol for amplifying, sequencing and analysing TCRs is described, which is robust, sensitive and versatile, and is applied to the analysis of human memory and naive subpopulations, and results in consistent measures of diversity and inequality.