M
Mattia Rocco
Researcher at National Cancer Research Institute
Publications - 81
Citations - 2090
Mattia Rocco is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Light scattering & Radius of gyration. The author has an hindex of 26, co-authored 76 publications receiving 1903 citations. Previous affiliations of Mattia Rocco include University of Geneva & University of Genoa.
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The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: Enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule
TL;DR: The implementation of the SOMO bead modeling suite within one of the most widely used analytical ultracentrifugation data analysis software packages, UltraScan, is reported, and the US-SOMO version is now under complete graphical interface control, and has been freed from several constraints present in the original implementation.
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SOMO (SOlution MOdeler) differences between X-Ray- and NMR-derived bead models suggest a role for side chain flexibility in protein hydrodynamics.
TL;DR: A method for generating medium-resolution models from the atomic coordinates of proteins, basically by using two nonoverlapping spheres of differing radii per residue, which has potential applications in the overall conformation and dynamics of modular/multidomain proteins and of supramolecular complexes.
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Dependence of the shape of the plasma fibronectin molecule on solvent composition. Ionic strength and glycerol content.
TL;DR: It is concluded that fibronectin can occur in two extreme conformations: the open form, in 30% glycerol at moderate ionic strength, should correspond to the extended shapes visualized by others by electron microscopy of samples prepared from solutions containing Glycerol, while the closed form occurs under more physiological conditions.
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Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization.
TL;DR: AlphaIIbbeta3 bead models were developed to describe quantitatively the ligand-induced transition from a "closed" to an "open" integrin conformation and the limited oligomerization that follows, which provides a new mechanistic framework for understanding integrin activation and the formation of signaling clusters on the surface of stimulated platelets.
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US-SOMO HPLC-SAXS module: Dealing with capillary fouling and extraction of pure component patterns from poorly resolved SEC-SAXS data
TL;DR: The US-SOMO HPLC-SAXS (high-performance liquid chromatography coupled with small-angle X-ray scattering) module is an advanced tool for the comprehensive analysis of SEC-SAZS (size-exclusion chromatography paired with SAXS) data.