M
Maureen Wellington
Publications - 22
Citations - 1467
Maureen Wellington is an academic researcher. The author has contributed to research in topics: Viral load & Drug resistance. The author has an hindex of 16, co-authored 21 publications receiving 1323 citations.
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Journal ArticleDOI
HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study
Raph L. Hamers,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Kishor Mandaliya,Francesca Conradie,Mariette E. Botes,Maureen Wellington,Akin Osibogun,Kim C. E. Sigaloff,Immaculate Nankya,Rob Schuurman,Ferdinand W. N. M. Wit,Wendy S. Stevens,Michèle van Vugt,Tobias F. Rinke de Wit +15 more
TL;DR: The higher prevalence of primary drug resistance in Uganda than in other African countries is probably related to the earlier start of ART roll-out in Uganda.
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Unnecessary Antiretroviral Treatment Switches and Accumulation of HIV Resistance Mutations; Two Arguments for Viral Load Monitoring in Africa
Kim C. E. Sigaloff,Raph L. Hamers,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Prudence Ive,Mariette E. Botes,Kishor Mandaliya,Maureen Wellington,Akin Osibogun,Wendy S. Stevens,Michèle van Vugt,Tobias F. Rinke de Wit +12 more
TL;DR: Prolonged treatment failure was indicated by extensive NRTI cross-resistance and access to virological monitoring should be expanded to prevent inappropriate switches, enable early failure detection and preserve second-line treatment options in Africa.
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Effect of pretreatment HIV-1 drug resistance on immunological virological and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study.
Raph L. Hamers,Rob Schuurman,Kim C. E. Sigaloff,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Kishor Mandaliya,Prudence Ive,Mariette E. Botes,Maureen Wellington,Akin Osibogun,Ferdinand W. N. M. Wit,Michèle van Vugt,Wendy S. Stevens,Tobias F. Rinke de Wit +14 more
TL;DR: Improved access to alternative combinations of antiretroviral drugs in sub-Saharan Africa is warranted and improved access to alternatives to pretreatment drug resistance is warranted.
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Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies
Raph L. Hamers,Kim C. E. Sigaloff,Annemarie M. J. Wensing,Carole L. Wallis,Cissy Kityo,Margaret Siwale,Kishor Mandaliya,Prudence Ive,Mariette E. Botes,Maureen Wellington,Akin Osibogun,Wendy S. Stevens,Tobias F. Rinke de Wit,Rob Schuurman +13 more
TL;DR: After stavudine failure in African populations, zidovudine rather than tenofovir may be preferred in second-line ART, and early failure detection limited the accumulation of resistance.
Journal ArticleDOI
Accumulation of HIV-1 drug resistance after continued virological failure on first-line ART in adults and children in sub-Saharan Africa.
T. Sonia Boender,Cissy Kityo,Ragna S. Boerma,Raph L. Hamers,Pascale Ondoa,Maureen Wellington,Margaret Siwale,Immaculate Nankya,Elizabeth Kaudha,Alani S Akanmu,Mariette E. Botes,Kim Steegen,Job C. J. Calis,Tobias F. Rinke de Wit,Kim C. E. Sigaloff +14 more
TL;DR: Improved VL monitoring to prevent accumulation of mutations, and new drug classes to construct fully active regimens, are required.