Mauricio Lozano

TL;DR: It is proposed that nuclear factor of activated T cells-5 (NFAT5), a well-known osmosensitive renal factor and recently characterized hypoxia-inducible protein, is also activated in vivo in placentas of PE and IUGR complications as well as in the in vitro model of trophoblasthypoxia.

TL;DR: IUGR increased the gene expression of HIF-1α, NFAT5, IL-1β, NGAL, and ATM in kidneys of fetuses undergoing IUGR, suggesting that fetal blood flow restriction produce alterations in gene expression in fetal kidneys.

TL;DR: This work aimed to study the effect of uteroplacental circulation restriction on endothelial kidney damage in a fetal rabbit model and found that it had an adverse effect on the integrity of the kidney walls.

TL;DR: This study investigated the role of oxidative damage and nitric oxide (NO) synthases in the fetal heart using a model of intrauterine growth restriction induced by uteroplacental circulation restriction (UCR).

TL;DR: Children with CKD undergoing PD therapy showed an impaired phosphorylation of JAK2/STAT5b signaling in fibroblasts after GH stimulation, as well as impaired IGFBP3 mRNA abundance, which may be partially responsible for the observed resistance to the growth-promoting actions of GH in chronic kidney failure.