Journal ArticleDOI
Intrauterine growth restriction modifies the normal gene expression in kidney from rabbit fetuses.
H. Figueroa,Mauricio Lozano,Cristian Suazo,Elisenda Eixarch,Sebastian E. Illanes,Juan Carreno,Sandra Villanueva,Edgar Hernandez-Andrade,Eduard Gratacós,Carlos E. Irarrazabal +9 more
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TLDR
IUGR increased the gene expression of HIF-1α, NFAT5, IL-1β, NGAL, and ATM in kidneys of fetuses undergoing IUGR, suggesting that fetal blood flow restriction produce alterations in gene expression in fetal kidneys.About:
This article is published in Early Human Development.The article was published on 2012-11-01. It has received 21 citations till now. The article focuses on the topics: Fetal Kidney & Intrauterine growth restriction.read more
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Journal ArticleDOI
In Utero Origins of Hypertension: Mechanisms and Targets for Therapy.
TL;DR: The current knowledge surrounding the developmental origins of hypertension is reviewed, with a focus on mechanistic pathways and targets for therapeutic and pharmacologic interventions.
Journal ArticleDOI
Placental Aromatase Is Deficient in Placental Ischemia and Preeclampsia.
Alejandra Pérez-Sepúlveda,Lara J. Monteiro,Aneta Dobierzewska,Pedro P. España-Perrot,Pia Venegas-Araneda,Alejandra M. Guzmán-Rojas,María González,Macarena Palominos-Rivera,Carlos E. Irarrazabal,H. Figueroa-Diesel,Manuel Varas-Godoy,Sebastian E. Illanes +11 more
TL;DR: Aromatase content was reduced in response to low oxygen tension in the choriocarcinoma JEG–3 cell line and in rabbit placentae in Response to partial ligation of uterine spiral arteries, suggesting that reduced placental aromatase activity in preeclamptic patients may be associated with chronic placental ischemia and hypoxia later in gestation.
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Models of Intrauterine growth restriction and fetal programming in rabbits.
TL;DR: The utility of the rabbit as a model organism for IUGR research is summarized and investigators are inspired to employ the rabbit when studying pregnancy physiology so that the understanding of mechanisms underlying IUBR and its consequences in humans and other mammalian species is advanced.
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Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury
David J. Askenazi,Catherine Morgan,Stuart L. Goldstein,David T. Selewski,Marva Moxey-Mims,Paul L. Kimmel,Robert A. Star,Rosemary D. Higgins,Matthew M. Laughon +8 more
TL;DR: Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury are proposed.
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Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis
Gunnar Schley,Holger Scholz,Andre Kraus,Thomas Hackenbeck,Bernd Klanke,Carsten Willam,Michael S. Wiesener,Eva Heinze,Nicolai Burzlaff,Kai-Uwe Eckardt,Bjoern Buchholz +10 more
TL;DR: It is found that HIF-1α is required for branching of MDCK cells, and the net effect of hypoxia-induced HIF activation in the embryonic kidney appears to be mesenchymal cell-dependent inhibition of ureter branching.
References
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Journal ArticleDOI
Fetal origins of adult disease: strength of effects and biological basis
TL;DR: The combination of small size at birth and during infancy, followed by accelerated weight gain from age 3 to 11 years, predicts large differences in the cumulative incidence of CHD, type 2 diabetes and hypertension.
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Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury
Jaya Mishra,Qing Ma,Anne E. Prada,Mark Mitsnefes,Kamyar Zahedi,Jun Yang,Jonathan Barasch,Prasad Devarajan +7 more
TL;DR: The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury.
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Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction
TL;DR: In this paper, the authors examined the association between intrauterine growth restriction and adverse neonatal outcomes in a population of 19,759 singleton very-low-birth-weight neonates without major birth defects.
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Growth in utero and serum cholesterol concentrations in adult life.
TL;DR: Raised serum cholesterol concentrations in adult life are associated with impaired growth during late gestation, when fetal undernutrition has a disproportionate effect on liver growth, which may permanently alter low density lipoprotein cholesterol metabolism.
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Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity
TL;DR: CDNA cloning of human TonE binding protein (TonEBP) is reported, a transcription factor that stimulates transcription through its binding to TonE sequences via a Rel-like DNA binding domain that plays a key role in hypertonicity-induced transcriptional stimulation of SMIT, sodium/chloride/betaine cotransporter, and aldose reductase.