Showing papers by "Mauro Serafini published in 2005"
TL;DR: It is concluded that dietary TAC is inversely and independently correlated with plasma concentrations of hs-CRP and this could be one of the mechanisms explaining the protective effects against CVD of antioxidant-rich foods such as fruits, whole cereals and red wine.
Abstract: Inflammation, a risk factor for cardiovascular disease, is associated with low plasma levels of antioxidant vitamins. In addition to vitamins, other antioxidants modulate the synthesis of inflammatory markers in vitro and contribute to the total antioxidant capacity (TAC) of a diet. However, the relationship between dietary TAC and markers of inflammation has never been evaluated in vivo. We investigated the relationship between dietary TAC and markers of systemic (high-sensitivity C-reactive protein (hs-CRP), leucocytes) and vascular (soluble intercellular cell adhesion molecule-1) inflammation in 243 non-diabetic subjects. General Linear Model (GLM) analysis showed a significant (P=0.005) inverse relationship between hs-CRP and quartiles of energy-adjusted dietary TAC, even when recognized modulating factors of inflammation, namely alcohol, fibre, vitamin C, alpha-tocopherol, beta-carotene, BMI, waist circumference, HDL-cholesterol, hypertension, insulin sensitivity and plasma beta-carotene, were included in the model as covariates (P=0.004). The relationship was stronger for subjects with hypertension (P=0.013 v. P=0.109 for normotensive individuals). Among dietary factors, TAC was significantly higher (5.3 (sd 3.0) v. 4.9 (sd 2.7) mmol Trolox/d; P=0.026) in subjects with low plasma hs-CRP (range: 0.0-4.1 mg/l) than in subjects with high plasma hs-CRP (range: 4.2-27.8 mg/l). We conclude that dietary TAC is inversely and independently correlated with plasma concentrations of hs-CRP and this could be one of the mechanisms explaining the protective effects against CVD of antioxidant-rich foods such as fruits, whole cereals and red wine. This could be of particular significance for subjects with high blood pressure.
208 citations
TL;DR: Two flavonoid glycosides containing acetylated allose, and two iridoid glucosides were obtained from a EtOH extract of Stachys corsica, an endemic plant of Sardinia and Corsica.
17 citations
TL;DR: The data of Dragsted et al clearly show that none of the measured redox markers were affected by the withdrawal of fruit and vegetables from the control diet, and it is speculated that 25 d was not an adequate time period to impair plasma TAC in healthy subjects.
9 citations
TL;DR: The phytochemical study of aerial parts of Viburnum sargenti Koehne, a species spontaneous in Mongolia and Northern China, led to the isolation of three iridoid glucosides of Valeriana-type: the novel 7,10,2′-triacetylsuspensolide F, 1, and the known viburtinoside IV and V.
5 citations
TL;DR: The results suggest that O. citrina could be a diverse entity and the presence of orobanchoside and verbascoside in all four species confirms that these PhGs are taxonomic markers of the genus.
5 citations
TL;DR: The phytochemical analysis of iridoidic fraction of the aerial parts of Vinca sardoa and VINCa difformis, gave the identification of loganic acid in V. dif formis as unique iridoids glucoside, while loganin is also present in V.'sardoa.
3 citations