Mauro Sousa de Almeida

TL;DR: In this paper, the physicochemical properties of nanoparticles have been discussed and the potential challenges of using various inhibitors, endocytic markers and genetic approaches to study endocytosis.

TL;DR: An inflamed human alveolar epithelium model is developed and the resolution of LPS-induced inflammation in vitro with a corticosteroid, methylprednisolone (MP) is tested, demonstrating that this model allows a meaningful comparison of the systemic vs. inhalation administration routes for the evaluation of the efficacy of a drug in vitro.

TL;DR: It is demonstrated that substrate stiffness can be used to regulate cellular endocytosis of particles in a size-dependent fashion and decreasing substrate rigidity and particle-based topography led to a reduction of focal adhesion size.

TL;DR: In this paper, a series of poly(N-isopropylacrylamide) (pNIPAM) particles with differing rigidity are self-assembled to form a defined particle-decorated surface.

TL;DR: Investigation of gene regulation in human macrophages and lung epithelial cells after acute exposure to spherical 60 nm SiO2 NPs found nuclear receptor NR4A1, an important modulator of inflammation in Macrophages, was found to be up-regulated.