Showing papers by "Max F. Perutz published in 1988"
TL;DR: It is of interest that the aromatic hydrogen bond arises from small partial charges centred on the ring carbon and hydrogen atoms: there is no need to consider delocalized electrons.
651 citations
TL;DR: Oral administration of LR16 (at small doses that produced no ill effects) to rats that were fed a diet rich in cholesterol caused substantial reductions of total serum cholesterol and low density lipoprotein-cholesterol, while high density cholesterol remained unchanged.
Abstract: 2-[4-(3,4-Dichlorophenylureido)phenoxy]-2-methylpropionic acid, LR16, combines with two symmetrically related sites in the central cavity of deoxyhemoglobin, 20 A away from the binding site of 2,3-bisphosphoglycerate, and acts as an allosteric effector synergistic with 2,3-bisphosphoglycerate. LR16 (1 mM) raises P50, the partial pressure of oxygen needed to achieve half-saturation with oxygen of a hemolysate of human hemoglobin, about 50 times more strongly than 1 mM 2,3-bisphosphoglycerate. Oral administration of LR16 (at small doses that produced no ill effects) to rats that were fed a diet rich in cholesterol caused substantial reductions of total serum cholesterol and low density lipoprotein-cholesterol, while high density lipoprotein-cholesterol remained unchanged.
52 citations
13 citations
9 citations
TL;DR: The X-ray study shows that the Haemoglobin North Chicago mutation produces unexpectedly large indirect changes in the T-structure, which is hard to conceive how such a small gap should raise the oxygen affinity significantly.
9 citations
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TL;DR: In Praise of Imperfection: My Life and Work as mentioned in this paper, by Rita Levi-Montalcini. Translated by Luigi Attardi. Pp.220.
Abstract: In Praise of Imperfection: My Life and Work. By Rita Levi-Montalcini. Translated by Luigi Attardi. Sloan Foundation Science Series/Basic Books: 1988. Pp.220. $18.95.
6 citations