May Chen

TL;DR: It is suggested that increases in PGC‐1, NRF‐ 1, andNRF‐2 represent key regulatory components of the stimulation of mitochondrial biogenesis by exercise and that P GC‐1 mediates the coordinated increases in GLUT4 and mitochondria.

TL;DR: It is found that feeding rats high-fat diets that cause muscle insulin resistance results in a concomitant gradual increase in muscle mitochondria, which is interpreted as evidence that raising free fatty acids results in an increase in mitochondria by activating PPARδ, which mediates a posttranscriptional increase in PGC-1α.

TL;DR: Results are interpreted as evidence that raising FFA induces an increase in mitochondrial biogenesis in muscle by activating PPARδ, as evidenced by increases in mitochondrial enzymes of the fatty acid oxidation pathway, citrate cycle, and respiratory chain.

TL;DR: Evidence is provided that ageing has differential effects on the three types of skeletal muscle fiber, and on weight-bearing and non-weight-bearing muscles, in the rat.

TL;DR: The results show that the adaptive response of L6 myotubes to an increase in cytosolic Ca2+ mimics the stimulation of mitochondrial biogenesis by exercise, which supports the hypothesis that an increases in cytOSolic Ca1+ is one of the signals that mediate increased mitochondrialBiogenesis in muscle.