M
Mayank M. Patel
Researcher at Anschutz Medical Campus
Publications - 5
Citations - 230
Mayank M. Patel is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Binding site & Genetic enhancement. The author has an hindex of 5, co-authored 5 publications receiving 226 citations. Previous affiliations of Mayank M. Patel include University of Colorado Boulder.
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Journal ArticleDOI
The stability of lyophilized lipid/DNA complexes during prolonged storage.
Marion d.C. Molina,Taylor K. Armstrong,Ye Zhang,Mayank M. Patel,Yvonne K. Lentz,Thomas J. Anchordoquy +5 more
TL;DR: Results from the stability study show that a progressive degradation of lipid/DNA complexes occurs in terms of transfection rates, particle size, dye accessibility, and supercoil content, even when samples are stored at low temperatures.
Journal ArticleDOI
Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse.
TL;DR: The contribution of the hydrophobic effect to multivalent cation- and cationic lipid-DNA binding and DNA collapse is elucidated by studying the thermodynamics of cobalt hexammine- and spermine-plasmid DNA binding at different temperatures.
Journal ArticleDOI
Ability of spermine to differentiate between DNA sequences--preferential stabilization of A-tracts.
TL;DR: These findings suggest a role for spermine in stabilization of non-nucleosomal A-tracts, and a compensating mechanism for incorporation of G-Tracts in the chromatin structure, and implications in sequence dependent DNA packaging are discussed.
Journal ArticleDOI
Degradation kinetics of high molecular weight poly(L-lactide) microspheres and release mechanism of lipid:DNA complexes
Mayank M. Patel,Michelle G. Zeles,Mark C. Manning,Theodore W. Randolph,Thomas J. Anchordoquy +4 more
TL;DR: No correlation was identified between release rate of soluble poly(L-lactide) species from PLLA and the DNA release kinetics, and the hydrophobicity of DOTAP:DNA complexes allowed consistently high encapsulation efficiencies to be achieved.
Book ChapterDOI
Formulation Considerations for DNA-Based Therapeutics
Thomas J. Anchordoquy,Taylor K. Armstrong,Marion d.C. Molina,S. Dean Allison,Ye Zhang,Mayank M. Patel,Yvonne K. Lentz,Gary S. Koe +7 more
TL;DR: The ability to deliver genes to cells and tissues in vivo offers the potential to develop potent vaccines and treat many hereditary diseases that are currently considered incurable, e.g., cancer, cystic fibrosis, severe combined immunodeficiency, and acquired immune deficiency syndrome.