Showing papers in "Journal of Pharmaceutical Sciences in 2004"

TL;DR: Development of formulations for protein drugs requiring high dosing may become challenging for solubility limited proteins and for the subcutaneous route with <1.5 mL allowable administration volume that requires >100 mg/mL protein concentrations.

TL;DR: The U.S. Food and Drug administration has approved several polyclonal antibody preparations and at least 18 monoclonal antibody preparations (antibodies, antibody fragments, antibody fusion proteins, etc.) which are associated with several interesting pharmacokinetic characteristics.

TL;DR: This minireview describes the physics associated with the preparation and storage of amorphous solids including a review of the common theories of the glass transition and relaxation processes.

TL;DR: There is a growing body of evidence that supports the important contribution of non-inclusion-based aspects for drug solubilization by cyclodextrins including surfactant-like effects and molecular aggregation.

TL;DR: A good correlation was obtained between drug formulation characteristics and findings from polymer-drug compatibility studies, as a means to guide formulation development.

TL;DR: Various coupling methods, covalent and noncovalent, will be reviewed, with emphasis on the major differences between the coupling reactions, on their advantages and drawbacks, on the coupling efficiency obtained, and on the importance of combining active targeting with long-circulating particles.

TL;DR: Extensive use of pharmacokinetic and exposure/response concepts in all phases of drug development has in the past been identified as a crucial factor for the success of a scientifically driven, evidence-based, and thus accelerated drug development process.

TL;DR: The solid-state drug-polymer solubility affects the nanoparticle characteristics, and thus could be used as an important preformulation parameter for drug delivery applications.

TL;DR: The combination of the two polymers provides a solid dispersion with good dissolution properties and improved physical stability compared with the binary solid dispersions of itraconazole.

TL;DR: In this paper, the effect of PEG chain length and PC content on physical properties and solubilization potential of sterically stabilized mixed micelles was investigated by using a fluorescent probe.

TL;DR: How PAMPA and Caco-2 can be synergistically applied for efficient and rapid investigation of permeation mechanisms in drug discovery is suggested.

TL;DR: Experimental methods for determining the steady-state volume of distribution and MRT(int), as well as the problem of determining whether peripheral drug elimination occurs, are considered and the equation for calculation of the tissue-plasma partition coefficient with the account of peripheral elimination is obtained.

TL;DR: The potential utility of in vitro digestion models to assess and rank order the in vivo performance of lipid solution and suspension formulations of poorly water-soluble drugs such as Hf is demonstrated.

TL;DR: In vivo study results indicate that amorphous solid dispersions containing 10-30% drug exhibited significant increases in area under the curve of concentration versus time (AUC) and maximum concentration (C(max)) over crystalline drug.

TL;DR: The log K(p) equation is compared to equations for various other processes, but it is found no process that appears to be similar to that for skin permeation and the nearest process to skin- water partition is the isobutanol-water partition system.

TL;DR: The ALOGPS 2.1 was developed to predict 1-octanol/water partition coefficients, logP, and aqueous solubility of neutral compounds and, using its ability to incorporate new user-provided data by means of self-learning properties of Associative Neural Networks, calculated a similar performance, RMSE = 0.7 and mean average error 0.5.

TL;DR: Referencing PXRD patterns computed from the refined single-crystal X-ray data for the title compounds are presented, which clarified previous findings relating to the polymorphism of this compound.

TL;DR: The performance of a dry powder inhaler can be affected by simple design changes, and CFD, coupled with experimental results, provides a rational basis for understanding the performance difference.

TL;DR: Pharmacological studies in vivo show that intercalation of the drug in the LDH reduces the ulcerating damage of theDrug.

TL;DR: Literature data related to the Biopharmaceutics Classification System (BCS) are presented on verapamil hydrochloride, propranolol hydrochlorides, and atenolol in the form of BCS-monographs.

TL;DR: Results indicate that Ad5 is stabilized by non-ionic surfactants and cryoprotectants as well as excipients known to inhibit free-radical oxidation, which should significantly enhance the utility of Ad5 as a vector for vaccines and gene therapy.

TL;DR: In this paper, the experimental inputs related to the constitutive model of the powder and the powder/tooling friction are determined, and the calibration techniques were developed based on a series of simple mechanical tests including diametrical compression, simple compression, and die compaction using an instrumented die.

TL;DR: The development and characterize of a solid lipid nanoparticle (SLN) system containing an anionic polymer for the delivery of cationic antineoplastic agents and chemosensitizers laid the foundation for a "one-bullet" dosage form that may provide convenient and effective delivery of multiple drug treatment of tumors.

TL;DR: The transdermal patches containing glibenclamide prevented the severe hypoglycemia in the initial hours and could maintain almost steady-state concentration of drug within the pharmacologically effective range for prolonged period of time, according to the pharmacokinetic evaluation.

TL;DR: The inhibition of crystallization of amorphous acetaminophen by polyvinylpyrrolidone and polyacrylic acid and the findings suggest that the stronger stabilizing effect of PAA is due to the stronger interaction with ACTA.

TL;DR: It is indicated that nonionic surfactants including Cremophor EL and Tween 80 may be useful pharmaceutical excipients for inhibiting the function of P- gp, thereby increasing the intestinal absorption of various drugs, which are secreted by a P-gp-mediated efflux system in the intestine.

TL;DR: The overall crystallization rates and mean relaxation times of amorphous nifedipine and phenobarbital in the presence of poly(vinylpyrrolidone) (PVP) were determined at various temperatures to gain further insight into the effect of molecular mobility on the crystallization rate of areorphous drugs and the possibility of predicting stability from their molecular mobility.

TL;DR: The salient features of the chemical reactions that are responsible for drug release from polymeric prodrugs employing various chemical linkages, esters, carbonates, carbamates, C=N linkage and amides are highlighted.

TL;DR: The influence of two structurally different anionic surfactants on the anhydrous-to-dihydrate transformation of carbamazepine was investigated and it was shown that both surfactant promoted the crystallization of CBZ dihydrate during dissolution of the anHydrous monoclinic polymorph.

TL;DR: The study showed that using lactose or microcrystalline cellulose in the formulations resulted in faster drug release profiles, and this effect may be imparted through synergistic interactions between Starch 1500 and HPMC and the filler actively forming an integral part within the H PMC gel structure.