M
Mckenna Longacre
Researcher at Brigham and Women's Hospital
Publications - 16
Citations - 2763
Mckenna Longacre is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 8, co-authored 16 publications receiving 2116 citations. Previous affiliations of Mckenna Longacre include Washington University in St. Louis & Harvard University.
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Journal ArticleDOI
Drug Resistance in Cancer: An Overview
Genevieve Housman,Shannon Byler,Sarah Heerboth,Karolina Lapinska,Mckenna Longacre,Nicole A. Snyder,Sibaji Sarkar +6 more
TL;DR: The current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA damage repair, cell death inhibition, and the epithelial-mesenchymal transition, as well as how inherent tumor cell heterogeneity plays a role in drug resistance are outlined.
Journal ArticleDOI
EMT and tumor metastasis.
Sarah Heerboth,Genevieve Housman,Meghan Leary,Mckenna Longacre,Shannon Byler,Karolina Lapinska,Amber Willbanks,Sibaji Sarkar +7 more
TL;DR: It is hypothesized that reversible epigenetic events regulate both EMT and MET, and thus, also regulate the development of different types of metastatic cancers.
Journal ArticleDOI
Cancer Development, Progression, and Therapy: An Epigenetic Overview
Sibaji Sarkar,Garrick Horn,Kimberly Moulton,Anuja Oza,Shannon Byler,Shannon Kokolus,Mckenna Longacre +6 more
TL;DR: It is proposed that predisposed normal cells convert to cancer progenitor cells that, after growing, undergo an epithelial-mesenchymal transition, which can create a metastatic form of both progenitors and full-fledged cancer cells, after which metastasis to a distant location may occur.
Journal ArticleDOI
A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis.
Mckenna Longacre,Nicole A. Snyder,Genevieve Housman,Meghan Leary,Karolina Lapinska,Sarah Heerboth,Amber Willbanks,Sibaji Sarkar +7 more
TL;DR: Comparisons of genetic, microenvironmental, stromal, and epigenetic changes common between breast and ovarian cancer cells suggest shared features of pathogenesis, and preliminary evidence suggests a shared epigenetic mechanism of oncogenesis.
Journal Article
Anti-breast cancer effects of histone deacetylase inhibitors and calpain inhibitor.
Megan A Mataga,Shoshana Rosenthal,Sarah Heerboth,Amrita Devalapalli,Shannon Kokolus,Leah R Evans,Mckenna Longacre,Genevieve Housman,Sibaji Sarkar +8 more
TL;DR: Results showed that the combination of HDACi and calpeptin inhibited the growth of two distinctly different types of breast cancer cells and could have wide clinical applications, though the mechanisms of inhibition are possibly different.