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Medardo Hernández

Researcher at Complutense University of Madrid

Publications -  115
Citations -  2829

Medardo Hernández is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Vasodilation & Receptor. The author has an hindex of 28, co-authored 115 publications receiving 2617 citations. Previous affiliations of Medardo Hernández include Aarhus University & Hospital General Universitario Gregorio Marañón.

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Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development

TL;DR: The view is supported that the system constituted by these receptors and their putative endogenous ligands might play a role in specific molecular events of the brain development, and that CB1 receptor sub type is located in neuronal cells obtained from fetal brain, although preliminary evidence is provided of the existence of another receptor subtype operative in glial cells obtainedfrom the cerebral cortex.
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Atypical location of cannabinoid receptors in white matter areas during rat brain development

TL;DR: The results indicated that specific binding for cannabinoid receptors can be detected in the brain of rat fetuses at GD21 in the classic areas that contain these receptors in adulthood, and the existence of a transient period of the brain development in the rat, around the last days of the fetal period and the first days of postnatal life, in which CB1 receptors appear located in neuronal fiber‐enriched areas.
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Motor behavior and nigrostriatal dopaminergic activity in adult rats perinatally exposed to cannabinoids

TL;DR: Whether neurochemical changes during ontogeny were accompanied by changes of motor behavior, the main neurobiological process regulated by nigrostriatal dopaminergic neurons; and persisted in adulthood, leading to disturbances in the expression of an adult motor activity is investigated.
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An acute dose of δ9-tetrahydrocannabinol affects behavioral and neurochemical indices of mesolimbic dopaminergic activity

TL;DR: It is concluded that acute THC markedly altered the behavioral pattern executed by the animals in a socio-sexual approach behavior test and in a dark-light emergence test, presumably indicating loss of sexual motivation and increased emotionality, although also accompanied by motor deficiencies.
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Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through different types of adrenoceptors.

TL;DR: The results suggest that noradrenaline may modulate both phasic peristaltic activity and basal tone of pig intravesical ureter through both α‐ and β‐adrenoceptors.