J.A. Ramos

TL;DR: The hypothesis that, in the brain, AEA is a metabolic product of NArPE and may reach levels compatible with its proposed neuromodulatory function is supported.

TL;DR: Analysis of CB1 receptor binding and mRNA expression by using autoradiography and in situ hybridization in the brain of rat fetuses and newborns shows that the endogenous cannabinoid system, constituted by endogenous ligands and receptor pathways, is present in the developing brain, which suggests a possible specific role this system in neural development.

TL;DR: The existence of subtle, sometimes more pronounced, sex dimorphisms, fluctuations along the ovarian cycle and changes after gonadectomy and sex steroid replacement in CNr density and affinity in certain brain areas is revealed and supports the hypothesis of possible sex steroid-dependent differences in the sensitivity of certain neuronal processes to cannabinoid treatment.

TL;DR: The results indicate that a nigro‐striatal lesion is associated with an increase in CB1 receptors in the basal ganglia in humans and nonhuman primates and that this increase could be reversed by chronic l‐DOPA therapy and suggest that CB1 receptor blockade might be useful as an adjuvant for the treatment of parkinsonian motor symptoms.

TL;DR: Data collectively support that expression of the CB(1) receptor gene in the anterior pituitary gland is regulated by sex steroids in both males and females and gonadal steroids appear to affect the response of this gene to chronic cannabinoid administration.