Megan Cross

TL;DR: Investigation of response stringency, quantified by the Oxford COVID-19 Government Response Tracker’s Stringency Index, and examined how restrictive interventions affected infection rates and gross domestic product (GDP) in China and OECD countries found that governments who responded to the pandemic faster saw greater reductions in viral transmission, but worse decreases in GDP.

TL;DR: It is concluded that both His74 and His185 are involved in triggering the pH changes to the conformational stability of wild-type CLIC1 via their protonation, which stabilizes the intermediate state.

TL;DR: By computationally screening a reasonably sized library of 1235 compounds against a panel of 48 mostly human kinases, this article is able to identify five groups of putative lead compounds with substantial diversity when compared to each other.

TL;DR: Analysis of the kinetics of trehalose-6-phosphate hydrolysis reveals that all five enzymes display a burst-like kinetic behaviour which is characterised by a decrease of the enzymatic rate after the pre-steady state, which can be explained by multiple global conformational changes in members of this enzyme family during substrate processing.

TL;DR: It is reported that the catalytic activity of the mycobacterial enzyme Rv1284 can be reversibly inhibited by oxidation and linked conditions of oxidative stress to pH homeostasis of the pathogen.