M
Megan Houseweart
Researcher at University of Utah
Publications - 2
Citations - 787
Megan Houseweart is an academic researcher from University of Utah. The author has contributed to research in topics: Capsid & Cyclophilin A. The author has an hindex of 2, co-authored 2 publications receiving 751 citations.
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Journal ArticleDOI
Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid
T.R. Gamble,Felix Vajdos,Sanghee Yoo,David K. Worthylake,Megan Houseweart,Wesley I. Sundquist,Christopher P. Hill +6 more
TL;DR: The structure suggests how cyclophilin A can act as a sequence-specific binding protein and a nonspecific prolyl isomerase, and in the crystal lattice, capsid molecules assemble into continuous planar strips.
Journal ArticleDOI
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
TL;DR: Comparison with the recently determined structures of CypA in complexes with larger fragments of the HIV‐1 capsid protein demonstrates that CypA recognition of these hexapeptides involves contacts with peptide residues Ala(Val) 88, Gly 89, and Pro 90, and is independent of the context of longer sequences.