Megan J. Barnden

TL;DR: Results show that successful generation of MHC class II‐restricted, OVA‐specific αβTCR transgenic mice was dependent upon combining cDNA‐ and genomic DNA‐based constructs for expression of the respective α‐ and β‐chains of the TCR.

TL;DR: Data indicate that control of such help is critical for the maintenance of CD8+ T cell tolerance induced by cross-presentation, and indicates that provision of help favored induction of autoimmunity.

TL;DR: Results suggest that a lower affinity TCR:MHC interaction may be necessary for positive selection in FTOC compared with selection in situ, and the ability to select in vitro correlated with the capacity to present the ovalbumin (OVA) peptide to OT‐I cells, as measured by induction of an OVA‐specific proliferative response.

TL;DR: A mechanism whereby developing thymocytes bearing an alphabetaTCR can modify their expression of the CD8 coreceptor to escape thymic deletion and achieve self-tolerance is suggested.

TL;DR: Both peripheral T cell activation and thymic deletion have an overall similar pattern of peptide specificity which differs from that required for positive selection, which suggests that a subset of major histocompatibility complex‐presented peptides could promote positive selection without causing either thymi deletion or peripheral activation of those selected T cells.