Megan Mitsak

TL;DR: Investigating the pathways of endoplasmic reticulum stress response, the unfolded protein response, and the ER overload response in muscle tissue of human myositis patients and in the mouse model indicates that the ER stress response may be a major nonimmune mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositIS.

TL;DR: It is shown by quantitative reverse transcriptase PCR that SANC express Ca2+-activated AC isoforms 1 and 8, in addition to AC type 2, 5, and 6 transcripts, and that ACs localize to membrane lipid microdomains.

TL;DR: Gene expression analysis demonstrated that genes that participate not only in angiogenesis but also in leukocyte trafficking and the complement cascade were highly up regulated in DM muscle in comparison to age matched controls.

TL;DR: This approach will permit correlation of virus glycosylation status with pathological severity and may serve as a rapid screen of viruses from physiological samples for further study by more advanced MS methodology.

TL;DR: The impact of α‐MHC overexpression on global cardiac protein expression is investigated and cardioprotective against tachycardia‐induced cardiomyopathy and mitochondrial energetics protein complement is investigated.